SPAG8 | OmnibusX

Name	Number of supported studies	Average coverage
ciliated cell	18 studies	44% ± 18%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SPAG8 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	99%	587.05	2625 / 2642	99%	7.38	701 / 705
thymus	100%	829.47	652 / 653	98%	5.42	594 / 605
ovary	100%	461.99	180 / 180	90%	4.52	385 / 430
prostate	98%	393.97	241 / 245	87%	2.05	435 / 502
kidney	99%	282.27	88 / 89	80%	2.64	723 / 901
adrenal gland	96%	229.99	247 / 258	79%	2.15	182 / 230
breast	90%	184.48	414 / 459	62%	1.61	691 / 1118
uterus	99%	596.19	169 / 170	49%	2.01	224 / 459
lung	96%	701.88	554 / 578	50%	1.61	581 / 1155
bladder	100%	282.33	21 / 21	36%	0.72	180 / 504
pancreas	61%	70.27	199 / 328	67%	1.68	120 / 178
intestine	92%	276.38	890 / 966	15%	0.30	80 / 527
skin	56%	63.24	1006 / 1809	47%	0.97	222 / 472
spleen	100%	254.26	240 / 241	0%	0	0 / 0
blood vessel	97%	207.86	1292 / 1335	0%	0	0 / 0
heart	89%	194.06	767 / 861	0%	0	0 / 0
stomach	73%	137.71	261 / 359	15%	0.21	43 / 286
esophagus	70%	178.94	1010 / 1445	14%	0.21	25 / 183
lymph node	0%	0	0 / 0	76%	1.45	22 / 29
adipose	74%	116.64	888 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	36%	0.69	29 / 80
liver	19%	17.53	42 / 226	14%	0.25	57 / 406
tonsil	0%	0	0 / 0	31%	0.52	14 / 45
muscle	30%	30.84	244 / 803	0%	0	0 / 0
peripheral blood	16%	17.05	151 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0007338	Biological process	single fertilization
GO_0007283	Biological process	spermatogenesis
GO_0030154	Biological process	cell differentiation
GO_0008150	Biological process	biological_process
GO_0045944	Biological process	positive regulation of transcription by RNA polymerase II
GO_0160111	Cellular component	axonemal A tubule inner sheath
GO_0005879	Cellular component	axonemal microtubule
GO_0005815	Cellular component	microtubule organizing center
GO_0001669	Cellular component	acrosomal vesicle
GO_0001673	Cellular component	male germ cell nucleus
GO_0016020	Cellular component	membrane
GO_0005819	Cellular component	spindle
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0008017	Molecular function	microtubule binding
GO_0005515	Molecular function	protein binding
GO_0003674	Molecular function	molecular_function

Gene name	SPAG8
Protein name	Sperm associated antigen 8 Sperm-associated antigen 8 (HSD-1) (Sperm membrane protein 1) (SMP-1) (Sperm membrane protein BS-84)
Synonyms
Description	FUNCTION: Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating . Plays a role in spermatogenesis by enhancing the binding of CREM isoform tau to its coactivator FHL5 and increasing the FHL5-regulated transcriptional activation of CREM isoform tau (By similarity). Involved in the acrosome reaction and in binding of sperm to the zona pellucida (By similarity). Plays a role in regulation of the cell cycle by controlling progression through the G2/M phase, possibly by delaying the activation of CDK1 which is required for entry into mitosis . May play a role in fertility and microtubule formation through interaction with RANBP9 . .
Accessions	Q99932 ENST00000472605.1 C9JAA8 ENST00000495667.5 ENST00000497810.1 ENST00000396638.7 [Q99932-3] F2Z302 ENST00000471631.1 ENST00000484764.5 F8WBP3 H7C4J6 ENST00000340291.6 [Q99932-2] ENST00000475644.5 [Q99932-1]

SPAG8 report