SP8 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SP8 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SP8 at tissue level.

III. Associated gene sets

GO_0009954Biological processproximal/distal pattern formation
GO_0030326Biological processembryonic limb morphogenesis
GO_0009953Biological processdorsal/ventral pattern formation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameSP8
Protein nameSP8 protein
Transcription factor Sp8 (Specificity protein 8)
Synonyms
DescriptionFUNCTION: Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity). .

AccessionsQ8IXZ3
Q4G0T0
ENST00000418710.3 [Q8IXZ3-4]
ENST00000361443.4 [Q8IXZ3-3]