SORCS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007218Biological processneuropeptide signaling pathway
GO_0006886Biological processintracellular protein transport
GO_0060292Biological processlong-term synaptic depression
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0043204Cellular componentperikaryon
GO_0031901Cellular componentearly endosome membrane
GO_0098839Cellular componentpostsynaptic density membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005829Cellular componentcytosol
GO_0043197Cellular componentdendritic spine
GO_0016020Cellular componentmembrane
GO_0008188Molecular functionneuropeptide receptor activity

IV. Literature review

[source]
Gene nameSORCS2
Protein nameAlternative protein SORCS2
Sortilin related VPS10 domain containing receptor 2
VPS10 domain-containing receptor SorCS2 [Cleaved into: SorCS2 122 kDa chain; SorCS2 104 kDa chain; SorCS2 18 kDa chain]
SynonymsKIAA1329
DescriptionFUNCTION: The heterodimer formed by NGFR and SORCS2 functions as receptor for the precursor forms of NGF (proNGF) and BDNF (proBDNF) . ProNGF and proBDNF binding both promote axon growth cone collapse (in vitro) . Plays a role in the regulation of dendritic spine density in hippocampus neurons (By similarity). Required for normal neurite branching and extension in response to BDNF . Plays a role in BDNF-dependent hippocampal synaptic plasticity. Together with NGFR and NTRK2, is required both for BDNF-mediated synaptic long-term depression and long-term potentiation . ProNGF binding promotes dissociation of TRIO from the heterodimer, which leads to inactivation of RAC1 and/or RAC2 and subsequent reorganization of the actin cytoskeleton . Together with the retromer complex subunit VPS35, required for normal expression of GRIN2A at synapses and dendritic cell membranes. Required for normal expression of the amino acid transporter SLC1A1 at the cell membrane, and thereby contributes to protect cells against oxidative stress (By similarity). .; FUNCTION: [SorCS2 122 kDa chain]: Does not promote Schwann cell apoptosis in response to proBDNF. .; FUNCTION: SorCS2 104 kDa chain and SorCS2 18 kDa chain together promote Schwann cell apoptosis in response to proBDNF. .

AccessionsENST00000505529.1
H0Y9I2
Q96PQ0
B5MED8
ENST00000329016.10
L8ECI9
ENST00000507866.6