SOAT2 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SOAT2 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
liver	96%	144.72	218 / 226	61%	13.35	248 / 406
kidney	92%	41.40	82 / 89	15%	0.36	131 / 901
uterus	99%	64.93	168 / 170	5%	0.38	21 / 459
breast	89%	50.75	409 / 459	11%	0.29	127 / 1118
spleen	100%	313.29	241 / 241	0%	0	0 / 0
bladder	95%	34.57	20 / 21	4%	0.18	21 / 504
blood vessel	99%	104.57	1316 / 1335	0%	0	0 / 0
prostate	97%	54.74	238 / 245	0%	0.00	1 / 502
thymus	85%	36.41	555 / 653	10%	0.17	62 / 605
stomach	76%	22.72	273 / 359	17%	1.28	50 / 286
esophagus	82%	35.80	1182 / 1445	9%	0.59	17 / 183
adipose	89%	43.85	1073 / 1204	0%	0	0 / 0
skin	70%	27.94	1263 / 1809	16%	0.74	75 / 472
ovary	82%	30.53	147 / 180	3%	0.06	14 / 430
intestine	75%	104.54	727 / 966	9%	0.60	45 / 527
lung	72%	21.29	416 / 578	4%	0.32	51 / 1155
peripheral blood	57%	29.27	530 / 929	0%	0	0 / 0
adrenal gland	39%	8.36	101 / 258	1%	0.01	2 / 230
heart	35%	7.38	299 / 861	0%	0	0 / 0
pancreas	19%	3.48	62 / 328	10%	0.23	17 / 178
muscle	14%	2.69	111 / 803	0%	0	0 / 0
lymph node	0%	0	0 / 0	14%	0.20	4 / 29
tonsil	0%	0	0 / 0	4%	0.07	2 / 45
brain	4%	0.66	93 / 2642	0%	0.00	3 / 705
eye	0%	0	0 / 0	3%	0.04	2 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0008203	Biological process	cholesterol metabolic process
GO_0010742	Biological process	macrophage derived foam cell differentiation
GO_0033344	Biological process	cholesterol efflux
GO_0034379	Biological process	very-low-density lipoprotein particle assembly
GO_0034383	Biological process	low-density lipoprotein particle clearance
GO_0030299	Biological process	intestinal cholesterol absorption
GO_0010878	Biological process	cholesterol storage
GO_0042632	Biological process	cholesterol homeostasis
GO_0005903	Cellular component	brush border
GO_0005783	Cellular component	endoplasmic reticulum
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0000062	Molecular function	fatty-acyl-CoA binding
GO_0004772	Molecular function	sterol O-acyltransferase activity
GO_0016746	Molecular function	acyltransferase activity
GO_0015485	Molecular function	cholesterol binding
GO_0005515	Molecular function	protein binding
GO_0034736	Molecular function	cholesterol O-acyltransferase activity

Gene name	SOAT2
Protein name	Sterol O-acyltransferase 2 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 2) (ACAT-2) (Cholesterol acyltransferase 2) Sterol O-acyltransferase 2
Synonyms	ACAT2 ACACT2
Description	FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol . Plays a role in lipoprotein assembly and dietary cholesterol absorption . Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) and linolenoyl-CoA ((9Z,12Z,15Z)-octadecatrienoyl-CoA) as substrates . May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa . .; FUNCTION: [Isoform 2]: Has lower enzymatic activity compared to isoform 1. .; FUNCTION: [Isoform 3]: Has lower enzymatic activity compared to isoform 1. .
Accessions	F8VPE9 ENST00000301466.8 [O75908-1] ENST00000551896.5 O75908 ENST00000542365.1 [O75908-4]

SOAT2 report