SOAT1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042632Biological processcholesterol homeostasis
GO_0008203Biological processcholesterol metabolic process
GO_0042986Biological processpositive regulation of amyloid precursor protein biosynthetic process
GO_0010742Biological processmacrophage derived foam cell differentiation
GO_0033344Biological processcholesterol efflux
GO_0034379Biological processvery-low-density lipoprotein particle assembly
GO_0034383Biological processlow-density lipoprotein particle clearance
GO_0010878Biological processcholesterol storage
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000062Molecular functionfatty-acyl-CoA binding
GO_0004772Molecular functionsterol O-acyltransferase activity
GO_0015485Molecular functioncholesterol binding
GO_0005515Molecular functionprotein binding
GO_0034736Molecular functioncholesterol O-acyltransferase activity

IV. Literature review

[source]
Gene nameSOAT1
Protein nameSterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1)
Sterol O-acyltransferase 1 (Acyl-coenzyme A:cholesterol acyltransferase 1) (Cholesterol acyltransferase 1)
SynonymsACACT
ACACT1
ACAT1
SOAT
STAT
ACAT
DescriptionFUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol . Plays a role in lipoprotein assembly and dietary cholesterol absorption . Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions . .

AccessionsENST00000367619.8 [P35610-1]
ENST00000540564.5 [P35610-2]
ENST00000539888.5 [P35610-3]
P35610
B1APM4
ENST00000426956.1