Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| macrophage | 21 studies | 26% ± 11% | |
| ciliated cell | 9 studies | 26% ± 10% | |
| microglial cell | 9 studies | 31% ± 12% | |
| alveolar macrophage | 8 studies | 34% ± 12% | |
| monocyte | 7 studies | 23% ± 6% | |
| classical monocyte | 7 studies | 24% ± 7% | |
| myeloid cell | 6 studies | 33% ± 11% | |
| dendritic cell | 5 studies | 21% ± 4% | |
| fibroblast | 4 studies | 25% ± 11% | |
| goblet cell | 4 studies | 24% ± 9% | |
| conventional dendritic cell | 3 studies | 22% ± 4% | |
| epithelial cell | 3 studies | 29% ± 9% | |
| tissue-resident macrophage | 3 studies | 20% ± 2% | |
| lymphocyte | 3 studies | 20% ± 4% | |
| GABAergic neuron | 3 studies | 31% ± 9% | |
| glutamatergic neuron | 3 studies | 31% ± 10% | |
| astrocyte | 3 studies | 25% ± 10% | |
| endothelial cell | 3 studies | 19% ± 1% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 6 studies | 22% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3234.14 | 244 / 245 | 100% | 81.29 | 502 / 502 |
| kidney | 100% | 1769.06 | 89 / 89 | 100% | 36.72 | 897 / 901 |
| pancreas | 100% | 2582.90 | 328 / 328 | 99% | 30.07 | 176 / 178 |
| lung | 100% | 4129.77 | 578 / 578 | 98% | 36.00 | 1135 / 1155 |
| thymus | 100% | 1718.64 | 652 / 653 | 98% | 16.64 | 594 / 605 |
| adrenal gland | 100% | 27901.95 | 258 / 258 | 97% | 73.89 | 223 / 230 |
| uterus | 100% | 2061.01 | 170 / 170 | 97% | 22.35 | 444 / 459 |
| breast | 100% | 2153.05 | 459 / 459 | 97% | 25.79 | 1080 / 1118 |
| bladder | 100% | 2193.71 | 21 / 21 | 91% | 20.90 | 459 / 504 |
| brain | 91% | 831.92 | 2417 / 2642 | 99% | 22.70 | 700 / 705 |
| skin | 92% | 2479.60 | 1666 / 1809 | 99% | 50.08 | 465 / 472 |
| liver | 100% | 1444.36 | 226 / 226 | 88% | 16.12 | 359 / 406 |
| stomach | 100% | 2317.45 | 359 / 359 | 86% | 16.89 | 247 / 286 |
| esophagus | 96% | 1272.29 | 1381 / 1445 | 91% | 19.46 | 166 / 183 |
| ovary | 100% | 2049.43 | 180 / 180 | 86% | 11.62 | 371 / 430 |
| intestine | 100% | 1897.78 | 966 / 966 | 84% | 15.63 | 445 / 527 |
| adipose | 100% | 2860.50 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 28.26 | 29 / 29 |
| spleen | 100% | 2757.34 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 2010.70 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 2539.69 | 906 / 929 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 96% | 18.84 | 43 / 45 |
| heart | 90% | 940.48 | 773 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 80% | 22.05 | 64 / 80 |
| muscle | 65% | 600.22 | 519 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0042632 | Biological process | cholesterol homeostasis |
| GO_0008203 | Biological process | cholesterol metabolic process |
| GO_0042986 | Biological process | positive regulation of amyloid precursor protein biosynthetic process |
| GO_0010742 | Biological process | macrophage derived foam cell differentiation |
| GO_0033344 | Biological process | cholesterol efflux |
| GO_0034379 | Biological process | very-low-density lipoprotein particle assembly |
| GO_0034383 | Biological process | low-density lipoprotein particle clearance |
| GO_0010878 | Biological process | cholesterol storage |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0016020 | Cellular component | membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0000062 | Molecular function | fatty-acyl-CoA binding |
| GO_0004772 | Molecular function | sterol O-acyltransferase activity |
| GO_0015485 | Molecular function | cholesterol binding |
| GO_0005515 | Molecular function | protein binding |
| GO_0034736 | Molecular function | cholesterol O-acyltransferase activity |
| Gene name | SOAT1 |
| Protein name | Sterol O-acyltransferase 1 (EC 2.3.1.26) (Acyl-coenzyme A:cholesterol acyltransferase 1) (ACAT-1) (Cholesterol acyltransferase 1) Sterol O-acyltransferase 1 (Acyl-coenzyme A:cholesterol acyltransferase 1) (Cholesterol acyltransferase 1) |
| Synonyms | ACACT ACACT1 ACAT1 SOAT STAT ACAT |
| Description | FUNCTION: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol . Plays a role in lipoprotein assembly and dietary cholesterol absorption . Utilizes oleoyl-CoA ((9Z)-octadecenoyl-CoA) preferentially as susbstrate: shows a higher activity towards an acyl-CoA substrate with a double bond at the delta-9 position (9Z) than towards saturated acyl-CoA or an unsaturated acyl-CoA with a double bond at the delta-7 (7Z) or delta-11 (11Z) positions . . |
| Accessions | ENST00000367619.8 [P35610-1] ENST00000540564.5 [P35610-2] ENST00000539888.5 [P35610-3] P35610 B1APM4 ENST00000426956.1 |