SNCB report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048488Biological processsynaptic vesicle endocytosis
GO_0051402Biological processneuron apoptotic process
GO_0042417Biological processdopamine metabolic process
GO_0007268Biological processchemical synaptic transmission
GO_0050808Biological processsynapse organization
GO_0043524Biological processnegative regulation of neuron apoptotic process
GO_0016234Cellular componentinclusion body
GO_0043679Cellular componentaxon terminus
GO_0005829Cellular componentcytosol
GO_0043025Cellular componentneuronal cell body
GO_0005737Cellular componentcytoplasm
GO_1903136Molecular functioncuprous ion binding
GO_0004859Molecular functionphospholipase inhibitor activity
GO_0005509Molecular functioncalcium ion binding
GO_0046914Molecular functiontransition metal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSNCB
Protein nameBeta-synuclein
Synonyms
DescriptionFUNCTION: Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.

AccessionsENST00000506696.1
ENST00000393693.7
G4Y815
ENST00000614675.4
Q16143
G4Y816
ENST00000510387.5
ENST00000310112.7