SMYD5 | OmnibusX

Name	Number of supported studies	Average coverage
glutamatergic neuron	3 studies	21% ± 5%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SMYD5 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	1482.76	1445 / 1445	100%	36.86	183 / 183
kidney	100%	1815.58	89 / 89	100%	37.62	901 / 901
lung	100%	1312.22	578 / 578	100%	39.33	1155 / 1155
ovary	100%	2610.51	180 / 180	100%	46.33	430 / 430
pancreas	100%	1289.20	328 / 328	100%	28.12	178 / 178
prostate	100%	2052.67	245 / 245	100%	33.16	502 / 502
skin	100%	1949.55	1809 / 1809	100%	49.69	472 / 472
thymus	100%	1784.25	653 / 653	100%	34.17	605 / 605
brain	100%	2132.78	2641 / 2642	100%	47.22	705 / 705
breast	100%	1896.08	459 / 459	100%	40.22	1117 / 1118
bladder	100%	2233.29	21 / 21	100%	42.32	503 / 504
uterus	100%	2134.64	170 / 170	100%	36.58	458 / 459
intestine	100%	1510.79	966 / 966	100%	39.88	525 / 527
adrenal gland	100%	2225.78	258 / 258	100%	29.14	229 / 230
stomach	99%	1136.20	357 / 359	100%	36.59	286 / 286
liver	100%	1007.53	226 / 226	98%	22.80	398 / 406
adipose	100%	1665.62	1204 / 1204	0%	0	0 / 0
eye	0%	0	0 / 0	100%	52.25	80 / 80
lymph node	0%	0	0 / 0	100%	36.94	29 / 29
spleen	100%	2027.68	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	29.22	45 / 45
ureter	0%	0	0 / 0	100%	37.02	1 / 1
blood vessel	100%	1424.96	1333 / 1335	0%	0	0 / 0
muscle	100%	1264.54	801 / 803	0%	0	0 / 0
heart	99%	1278.66	849 / 861	0%	0	0 / 0
peripheral blood	68%	796.18	628 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0045814	Biological process	negative regulation of gene expression, epigenetic
GO_0141005	Biological process	retrotransposon silencing by heterochromatin formation
GO_0032259	Biological process	methylation
GO_2000035	Biological process	regulation of stem cell division
GO_2000736	Biological process	regulation of stem cell differentiation
GO_0005575	Cellular component	cellular_component
GO_0042799	Molecular function	histone H4K20 methyltransferase activity
GO_0005515	Molecular function	protein binding
GO_0140943	Molecular function	histone H4K20 trimethyltransferase activity
GO_0046872	Molecular function	metal ion binding

Gene name	SMYD5
Protein name	Histone-lysine N-trimethyltransferase SMYD5 (EC 2.1.1.372) (Protein NN8-4AG) (Retinoic acid-induced protein 15) (SET and MYND domain-containing protein 5) ([histone H4]-lysine20 N-trimethyltransferase SMYD5) SMYD family member 5
Synonyms	RAI15
Description	FUNCTION: Histone methyltransferase that specifically trimethylates 'Lys-20' of histone H4 to form trimethylated histone H4 lysine 20 (H4K20me3) which represents a specific tag for epigenetic transcriptional repression (By similarity). In association with the NCoR corepressor complex, is involved in the repression of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the formation of H4K20me3 at the gene promoters (By similarity). Plays an important role in embryonic stem (ES) cell self-renewal and differentiation (By similarity). Promotes ES cell maintenance by silencing differentiation genes through deposition of H4K20me3 marks (By similarity). Maintains genome stability of ES cells during differentiation through regulation of heterochromatin formation and repression of endogenous repetitive DNA elements by depositing H4K20me3 marks . .
Accessions	ENST00000389501.9 ENST00000413491.5 ENST00000258100.8 F8WEJ9 ENST00000443900.1 C9IYN9 ENST00000629411.2 Q6GMV2 E2QRN5

SMYD5 report