Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| plasmacytoid dendritic cell | 20 studies | 60% ± 15% | |
| retina horizontal cell | 6 studies | 47% ± 5% | |
| interneuron | 4 studies | 21% ± 4% | |
| neuron | 4 studies | 26% ± 6% | |
| GABAergic neuron | 4 studies | 33% ± 9% | |
| glutamatergic neuron | 4 studies | 44% ± 10% | |
| rod bipolar cell | 3 studies | 24% ± 3% | |
| mesothelial cell | 3 studies | 25% ± 6% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 5 studies | 28% ± 11% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| intestine | 92% | 3075.66 | 885 / 966 | 94% | 18.15 | 494 / 527 |
| prostate | 93% | 1210.34 | 229 / 245 | 90% | 11.08 | 451 / 502 |
| stomach | 87% | 2473.77 | 313 / 359 | 91% | 19.31 | 260 / 286 |
| brain | 95% | 2339.69 | 2502 / 2642 | 81% | 10.59 | 570 / 705 |
| pancreas | 42% | 242.55 | 139 / 328 | 87% | 16.69 | 155 / 178 |
| breast | 73% | 726.18 | 334 / 459 | 50% | 4.75 | 560 / 1118 |
| adrenal gland | 45% | 298.72 | 116 / 258 | 70% | 22.50 | 160 / 230 |
| lung | 74% | 609.94 | 429 / 578 | 38% | 5.64 | 441 / 1155 |
| ovary | 96% | 1183.06 | 172 / 180 | 11% | 0.88 | 46 / 430 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.09 | 1 / 1 |
| thymus | 84% | 707.74 | 549 / 653 | 15% | 15.51 | 91 / 605 |
| esophagus | 47% | 282.01 | 683 / 1445 | 51% | 12.58 | 94 / 183 |
| spleen | 98% | 820.33 | 236 / 241 | 0% | 0 | 0 / 0 |
| uterus | 72% | 608.89 | 123 / 170 | 24% | 2.43 | 109 / 459 |
| bladder | 57% | 349.24 | 12 / 21 | 36% | 5.30 | 181 / 504 |
| skin | 72% | 2207.51 | 1302 / 1809 | 12% | 1.01 | 56 / 472 |
| liver | 69% | 853.90 | 155 / 226 | 7% | 1.12 | 29 / 406 |
| adipose | 64% | 916.77 | 765 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 38% | 3.29 | 11 / 29 |
| muscle | 32% | 234.92 | 260 / 803 | 0% | 0 | 0 / 0 |
| kidney | 30% | 222.66 | 27 / 89 | 1% | 0.06 | 10 / 901 |
| peripheral blood | 29% | 236.24 | 272 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 21% | 115.14 | 278 / 1335 | 0% | 0 | 0 / 0 |
| heart | 16% | 96.46 | 140 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 4% | 0.24 | 3 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.13 | 1 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_1901653 | Biological process | cellular response to peptide |
| GO_0006685 | Biological process | sphingomyelin catabolic process |
| GO_0002244 | Biological process | hematopoietic progenitor cell differentiation |
| GO_0070314 | Biological process | G1 to G0 transition |
| GO_0140014 | Biological process | mitotic nuclear division |
| GO_0006684 | Biological process | sphingomyelin metabolic process |
| GO_0085029 | Biological process | extracellular matrix assembly |
| GO_0048661 | Biological process | positive regulation of smooth muscle cell proliferation |
| GO_0097187 | Biological process | dentinogenesis |
| GO_0006672 | Biological process | ceramide metabolic process |
| GO_0035264 | Biological process | multicellular organism growth |
| GO_0001932 | Biological process | regulation of protein phosphorylation |
| GO_0001958 | Biological process | endochondral ossification |
| GO_0003433 | Biological process | chondrocyte development involved in endochondral bone morphogenesis |
| GO_0015774 | Biological process | polysaccharide transport |
| GO_1903543 | Biological process | positive regulation of exosomal secretion |
| GO_0071286 | Biological process | cellular response to magnesium ion |
| GO_0071461 | Biological process | cellular response to redox state |
| GO_0051898 | Biological process | negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction |
| GO_0048008 | Biological process | platelet-derived growth factor receptor signaling pathway |
| GO_0030509 | Biological process | BMP signaling pathway |
| GO_0071356 | Biological process | cellular response to tumor necrosis factor |
| GO_0071897 | Biological process | DNA biosynthetic process |
| GO_0030072 | Biological process | peptide hormone secretion |
| GO_0098868 | Biological process | bone growth |
| GO_0002685 | Biological process | regulation of leukocyte migration |
| GO_0030282 | Biological process | bone mineralization |
| GO_0090520 | Biological process | sphingolipid mediated signaling pathway |
| GO_0061035 | Biological process | regulation of cartilage development |
| GO_0140052 | Biological process | cellular response to oxidised low-density lipoprotein particle stimulus |
| GO_1900126 | Biological process | negative regulation of hyaluronan biosynthetic process |
| GO_0045840 | Biological process | positive regulation of mitotic nuclear division |
| GO_0070301 | Biological process | cellular response to hydrogen peroxide |
| GO_0032963 | Biological process | collagen metabolic process |
| GO_0048286 | Biological process | lung alveolus development |
| GO_0005576 | Cellular component | extracellular region |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0000137 | Cellular component | Golgi cis cisterna |
| GO_0000139 | Cellular component | Golgi membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004767 | Molecular function | sphingomyelin phosphodiesterase activity |
| GO_0061751 | Molecular function | neutral sphingomyelin phosphodiesterase activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0001786 | Molecular function | phosphatidylserine binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0008081 | Molecular function | phosphoric diester hydrolase activity |
| GO_0070300 | Molecular function | phosphatidic acid binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SMPD3 |
| Protein name | Sphingomyelin phosphodiesterase Sphingomyelin phosphodiesterase 3 (EC 3.1.4.12) (Neutral sphingomyelinase 2) (nSMase-2) (nSMase2) (Neutral sphingomyelinase II) Neutral sphingomyelinase type 2 sphingomyelin phosphodiesterase (EC 3.1.4.12) Sphingomyelin phosphodiesterase 3 |
| Synonyms | |
| Description | FUNCTION: Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization . Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity). . |
| Accessions | H3BTM0 ENST00000574662.1 D6Q0F1 C8CHW6 I3L228 ENST00000568373.5 ENST00000563226.1 [Q9NY59-2] Q9NY59 ENST00000561749.1 H3BS51 ENST00000219334.10 [Q9NY59-1] |
