I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| ciliated cell | 11 studies | 28% ± 11% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| ciliated cell | 11 studies | 28% ± 11% |
Insufficient scRNA-seq data for expression of SMPD2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| pancreas | 100% | 646.18 | 328 / 328 | 100% | 21.09 | 178 / 178 |
| prostate | 100% | 890.51 | 245 / 245 | 100% | 34.81 | 502 / 502 |
| thymus | 100% | 911.98 | 653 / 653 | 100% | 21.58 | 605 / 605 |
| uterus | 100% | 556.85 | 170 / 170 | 100% | 22.00 | 458 / 459 |
| ovary | 100% | 458.90 | 180 / 180 | 100% | 18.16 | 429 / 430 |
| breast | 100% | 575.67 | 459 / 459 | 100% | 26.27 | 1115 / 1118 |
| stomach | 100% | 600.60 | 358 / 359 | 100% | 25.96 | 286 / 286 |
| skin | 100% | 949.47 | 1809 / 1809 | 100% | 23.70 | 470 / 472 |
| intestine | 100% | 600.41 | 965 / 966 | 100% | 32.10 | 525 / 527 |
| kidney | 100% | 700.36 | 89 / 89 | 99% | 16.09 | 896 / 901 |
| bladder | 100% | 550.05 | 21 / 21 | 99% | 28.42 | 501 / 504 |
| lung | 100% | 668.19 | 577 / 578 | 100% | 20.14 | 1150 / 1155 |
| esophagus | 100% | 724.37 | 1440 / 1445 | 99% | 17.48 | 182 / 183 |
| adrenal gland | 100% | 530.32 | 258 / 258 | 96% | 10.05 | 220 / 230 |
| brain | 94% | 260.20 | 2488 / 2642 | 98% | 9.72 | 693 / 705 |
| liver | 98% | 265.17 | 221 / 226 | 91% | 10.49 | 368 / 406 |
| eye | 0% | 0 | 0 / 0 | 100% | 31.17 | 80 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 27.80 | 29 / 29 |
| spleen | 100% | 839.66 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 19.23 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 9.98 | 1 / 1 |
| adipose | 100% | 413.32 | 1201 / 1204 | 0% | 0 | 0 / 0 |
| peripheral blood | 98% | 552.45 | 910 / 929 | 0% | 0 | 0 / 0 |
| blood vessel | 98% | 306.46 | 1306 / 1335 | 0% | 0 | 0 / 0 |
| heart | 94% | 255.14 | 808 / 861 | 0% | 0 | 0 / 0 |
| muscle | 56% | 126.87 | 452 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006685 | Biological process | sphingomyelin catabolic process |
| GO_0030149 | Biological process | sphingolipid catabolic process |
| GO_0006684 | Biological process | sphingomyelin metabolic process |
| GO_0046513 | Biological process | ceramide biosynthetic process |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0071944 | Cellular component | cell periphery |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005901 | Cellular component | caveola |
| GO_0004767 | Molecular function | sphingomyelin phosphodiesterase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0008081 | Molecular function | phosphoric diester hydrolase activity |
| Gene name | SMPD2 |
| Protein name | Sphingomyelin phosphodiesterase 2 (EC 3.1.4.12) (Lyso-platelet-activating factor-phospholipase C) (Lyso-PAF-PLC) (Neutral sphingomyelinase) (N-SMase) (nSMase) (nSMase1) Sphingomyelin phosphodiesterase 2 |
| Synonyms | |
| Description | FUNCTION: Catalyzes, at least in vitro, the hydrolysis of sphingomyelin to form ceramide and phosphocholine . Also hydrolyzes 1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine (lyso-platelet-activating factor) in vivo . Also acts on 1-acyl-2-lyso-sn-glycero-3-phosphocholine (lyso-PC) and sphingosylphosphocholine . . |
| Accessions | O60906 ENST00000258052.8 ENST00000458487.1 H0Y5N2 |
