SMC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_1905821Biological processpositive regulation of chromosome condensation
GO_0045132Biological processmeiotic chromosome segregation
GO_0010032Biological processmeiotic chromosome condensation
GO_0051301Biological processcell division
GO_0051984Biological processpositive regulation of chromosome segregation
GO_1905820Biological processpositive regulation of chromosome separation
GO_0007076Biological processmitotic chromosome condensation
GO_0051383Biological processkinetochore organization
GO_0005730Cellular componentnucleolus
GO_0000228Cellular componentnuclear chromosome
GO_0070062Cellular componentextracellular exosome
GO_0005654Cellular componentnucleoplasm
GO_0000796Cellular componentcondensin complex
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0000794Cellular componentcondensed nuclear chromosome
GO_0000793Cellular componentcondensed chromosome
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0003682Molecular functionchromatin binding
GO_0003697Molecular functionsingle-stranded DNA binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameSMC2
Protein nameStructural maintenance of chromosomes protein
SMC2 protein
Structural maintenance of chromosomes protein 2 (SMC protein 2) (SMC-2) (Chromosome-associated protein E) (hCAP-E) (XCAP-E homolog)
Structural maintenance of chromosomes 2
SynonymsCAPE
PRO0324
SMC2L1
DescriptionFUNCTION: Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. .

AccessionsO95347
Q05D74
Q6IPS5
Q05BV1
A0A0C4DGE5
ENST00000286398.11 [O95347-1]
B7ZLZ7
A0JLM9
ENST00000374793.8 [O95347-1]
ENST00000493955.1
Q6P712
Q32Q15
Q7Z2X1
ENST00000374787.7 [O95347-1]
Q5T821
ENST00000440179.5