SLX1A | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLX1A at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
bladder	100%	30.48	21 / 21	0%	0	0 / 504
spleen	100%	66.54	241 / 241	0%	0	0 / 0
thymus	100%	50.32	652 / 653	0%	0	0 / 605
prostate	100%	44.36	244 / 245	0%	0	0 / 502
intestine	99%	37.86	960 / 966	0%	0.00	1 / 527
breast	100%	29.17	457 / 459	0%	0	0 / 1118
uterus	99%	31.48	169 / 170	0%	0	0 / 459
liver	99%	25.85	224 / 226	0%	0	0 / 406
stomach	99%	25.11	355 / 359	0%	0	0 / 286
lung	99%	37.27	570 / 578	0%	0	0 / 1155
esophagus	98%	26.40	1423 / 1445	0%	0	0 / 183
adrenal gland	98%	24.53	253 / 258	0%	0	0 / 230
peripheral blood	98%	31.36	909 / 929	0%	0	0 / 0
ovary	98%	23.98	176 / 180	0%	0	0 / 430
adipose	98%	28.27	1177 / 1204	0%	0	0 / 0
kidney	97%	34.07	86 / 89	0%	0	0 / 901
skin	97%	20.39	1746 / 1809	0%	0	0 / 472
blood vessel	96%	20.58	1285 / 1335	0%	0	0 / 0
pancreas	96%	20.34	314 / 328	0%	0	0 / 178
heart	91%	15.52	780 / 861	0%	0	0 / 0
brain	89%	21.38	2356 / 2642	0%	0	0 / 705
muscle	84%	14.63	675 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
eye	0%	0	0 / 0	0%	0	0 / 80
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
tonsil	0%	0	0 / 0	0%	0	0 / 45
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0000724	Biological process	double-strand break repair via homologous recombination
GO_0010792	Biological process	DNA double-strand break processing involved in repair via single-strand annealing
GO_0061820	Biological process	telomeric D-loop disassembly
GO_0090656	Biological process	t-circle formation
GO_0006281	Biological process	DNA repair
GO_0010833	Biological process	telomere maintenance via telomere lengthening
GO_1904431	Biological process	positive regulation of t-circle formation
GO_1904357	Biological process	negative regulation of telomere maintenance via telomere lengthening
GO_0005654	Cellular component	nucleoplasm
GO_0033557	Cellular component	Slx1-Slx4 complex
GO_0005515	Molecular function	protein binding
GO_0008821	Molecular function	crossover junction DNA endonuclease activity
GO_0017108	Molecular function	5'-flap endonuclease activity
GO_0046872	Molecular function	metal ion binding

Gene name	SLX1A
Protein name	SLX1 homolog A, structure-specific endonuclease subunit Structure-specific endonuclease subunit SLX1 (EC 3.1.-.-) (GIY-YIG domain-containing protein 1)
Synonyms	GIYD1 SLX1; SLX1B GIYD2 SLX1
Description	FUNCTION: Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. Has a preference for 5'-flap structures, and promotes symmetrical cleavage of static and migrating Holliday junctions (HJs). Resolves HJs by generating two pairs of ligatable, nicked duplex products. .
Accessions	ENST00000330181.10 [Q9BQ83-1] Q9BQ83 ENST00000251303.11 [Q9BQ83-1] ENST00000563995.1 H3BPC3 ENST00000351581.4 [Q9BQ83-2] ENST00000345535.8 [Q9BQ83-2]

SLX1A report