SLURP1 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLURP1 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLURP1 at tissue level.

III. Associated gene sets

GO_0030336Biological processnegative regulation of cell migration
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0001775Biological processcell activation
GO_0038195Biological processurokinase plasminogen activator signaling pathway
GO_0007155Biological processcell adhesion
GO_0007626Biological processlocomotory behavior
GO_0050884Biological processneuromuscular process controlling posture
GO_0010839Biological processnegative regulation of keratinocyte proliferation
GO_0005615Cellular componentextracellular space
GO_0070062Cellular componentextracellular exosome
GO_0005576Cellular componentextracellular region
GO_0005515Molecular functionprotein binding
GO_0030549Molecular functionacetylcholine receptor activator activity
GO_0005125Molecular functioncytokine activity

IV. Literature review

[source]
Gene nameSLURP1
Protein nameSecreted Ly-6/uPAR-related protein 1 (SLURP-1) (ARS component B) (ARS(component B)-81/S) (Anti-neoplastic urinary protein) (ANUP)
SynonymsARS
DescriptionFUNCTION: Has an antitumor activity . Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin . In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner . In T cells may be involved in regulation of intracellular Ca(2+) signaling . Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation . .

AccessionsP55000
ENST00000246515.2