SLIT2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001657Biological processureteric bud development
GO_0030837Biological processnegative regulation of actin filament polymerization
GO_0014912Biological processnegative regulation of smooth muscle cell migration
GO_0050772Biological processpositive regulation of axonogenesis
GO_0050929Biological processinduction of negative chemotaxis
GO_0048754Biological processbranching morphogenesis of an epithelial tube
GO_0035385Biological processRoundabout signaling pathway
GO_0043116Biological processnegative regulation of vascular permeability
GO_0070100Biological processnegative regulation of chemokine-mediated signaling pathway
GO_0071676Biological processnegative regulation of mononuclear cell migration
GO_0002042Biological processcell migration involved in sprouting angiogenesis
GO_0071504Biological processcellular response to heparin
GO_0090260Biological processnegative regulation of retinal ganglion cell axon guidance
GO_0003180Biological processaortic valve morphogenesis
GO_0002689Biological processnegative regulation of leukocyte chemotaxis
GO_0032870Biological processcellular response to hormone stimulus
GO_0021834Biological processchemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
GO_0021972Biological processcorticospinal neuron axon guidance through spinal cord
GO_0048846Biological processaxon extension involved in axon guidance
GO_0050919Biological processnegative chemotaxis
GO_0010593Biological processnegative regulation of lamellipodium assembly
GO_0021836Biological processchemorepulsion involved in postnatal olfactory bulb interneuron migration
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0060412Biological processventricular septum morphogenesis
GO_0030336Biological processnegative regulation of cell migration
GO_0003184Biological processpulmonary valve morphogenesis
GO_0008045Biological processmotor neuron axon guidance
GO_0010596Biological processnegative regulation of endothelial cell migration
GO_0071672Biological processnegative regulation of smooth muscle cell chemotaxis
GO_0031290Biological processretinal ganglion cell axon guidance
GO_0090027Biological processnegative regulation of monocyte chemotaxis
GO_0051058Biological processnegative regulation of small GTPase mediated signal transduction
GO_0043065Biological processpositive regulation of apoptotic process
GO_0051414Biological processresponse to cortisol
GO_0061364Biological processapoptotic process involved in luteolysis
GO_0090024Biological processnegative regulation of neutrophil chemotaxis
GO_0007411Biological processaxon guidance
GO_0090288Biological processnegative regulation of cellular response to growth factor stimulus
GO_0030308Biological processnegative regulation of cell growth
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005737Cellular componentcytoplasm
GO_0008201Molecular functionheparin binding
GO_0042803Molecular functionprotein homodimerization activity
GO_0005095Molecular functionGTPase inhibitor activity
GO_0042802Molecular functionidentical protein binding
GO_0048495Molecular functionRoundabout binding
GO_0043237Molecular functionlaminin-1 binding
GO_0043394Molecular functionproteoglycan binding
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLIT2
Protein nameSlit homolog 2 protein (Slit-2) [Cleaved into: Slit homolog 2 protein N-product; Slit homolog 2 protein C-product]
Slit guidance ligand 2
Uncharacterized protein SLIT2
SynonymsSLIL3
DescriptionFUNCTION: Thought to act as molecular guidance cue in cellular migration, and function appears to be mediated by interaction with roundabout homolog receptors. During neural development involved in axonal navigation at the ventral midline of the neural tube and projection of axons to different regions. SLIT1 and SLIT2 seem to be essential for midline guidance in the forebrain by acting as repulsive signal preventing inappropriate midline crossing by axons projecting from the olfactory bulb. In spinal cord development may play a role in guiding commissural axons once they reached the floor plate by modulating the response to netrin. In vitro, silences the attractive effect of NTN1 but not its growth-stimulatory effect and silencing requires the formation of a ROBO1-DCC complex. May be implicated in spinal cord midline post-crossing axon repulsion. In vitro, only commissural axons that crossed the midline responded to SLIT2. In the developing visual system appears to function as repellent for retinal ganglion axons by providing a repulsion that directs these axons along their appropriate paths prior to, and after passage through, the optic chiasm. In vitro, collapses and repels retinal ganglion cell growth cones. Seems to play a role in branching and arborization of CNS sensory axons, and in neuronal cell migration. In vitro, Slit homolog 2 protein N-product, but not Slit homolog 2 protein C-product, repels olfactory bulb (OB) but not dorsal root ganglia (DRG) axons, induces OB growth cones collapse and induces branching of DRG axons. Seems to be involved in regulating leukocyte migration. .

AccessionsENST00000504154.6 [O94813-1]
F5H0U4
ENST00000508824.1
ENST00000273739.9
ENST00000509941.1
H0Y968
ENST00000503823.5 [O94813-3]
H0Y9Z6
ENST00000511508.5
X6R3P0
E9PCX4
Q4W5K2
Q4W5N0
ENST00000622093.4
A0A087WYV5
O94813
ENST00000503837.5 [O94813-2]
ENST00000512993.1