SLFN11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLFN11 at tissue level.

III. Associated gene sets

GO_0006338Biological processchromatin remodeling
GO_2000134Biological processnegative regulation of G1/S transition of mitotic cell cycle
GO_0051607Biological processdefense response to virus
GO_0002376Biological processimmune system process
GO_0006974Biological processDNA damage response
GO_0043111Biological processreplication fork arrest
GO_0008156Biological processnegative regulation of DNA replication
GO_0090734Cellular componentsite of DNA damage
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005634Cellular componentnucleus
GO_0003677Molecular functionDNA binding
GO_0000049Molecular functiontRNA binding
GO_0004386Molecular functionhelicase activity
GO_0005515Molecular functionprotein binding
GO_0004519Molecular functionendonuclease activity
GO_0016887Molecular functionATP hydrolysis activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameSLFN11
Protein nameSchlafen family member 11 (EC 3.6.-.-)
Schlafen family member 11
Synonyms
DescriptionFUNCTION: Inhibitor of DNA replication that promotes cell death in response to DNA damage . Acts as a guardian of the genome by killing cells with defective replication . Persistently blocks stressed replication forks by opening chromatin across replication initiation sites at stressed replication forks, possibly leading to unwind DNA ahead of the MCM helicase and block fork progression, ultimately leading to cell death . Acts independently of ATR . Also acts as an interferon (IFN)-induced antiviral protein which acts as an inhibitor of retrovirus protein synthesis . Specifically abrogates the production of retroviruses such as human immunodeficiency virus 1 (HIV-1) by acting as a specific inhibitor of the synthesis of retroviruses encoded proteins in a codon-usage-dependent manner . Binds to tRNAs and exploits the unique viral codon bias towards A/T nucleotides . The exact inhibition mechanism is unclear: may either sequester tRNAs, prevent their maturation via post-transcriptional processing or may accelerate their deacylation . Does not inhibit reverse transcription, integration or production and nuclear export of viral RNA . .

AccessionsQ7Z7L1
ENST00000430814.5
K7ES87
ENST00000394566.5
ENST00000591682.5
ENST00000441608.6
ENST00000592108.1
ENST00000589811.5
ENST00000588579.1
K7EJJ3
ENST00000308377.8
C9JUT2
ENST00000427966.5
K7EKT7
C9JDG6
ENST00000685675.1
C9J902
K7ER38
ENST00000592122.1
K7EIM3