SLCO2B1 | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
macrophage	40 studies	45% ± 18%	Explore
microglial cell	15 studies	61% ± 18%	Explore
endothelial cell of lymphatic vessel	13 studies	28% ± 10%	Explore
myeloid cell	13 studies	40% ± 16%	Explore
endothelial cell	11 studies	40% ± 15%	Explore
mast cell	10 studies	36% ± 20%	Explore
alveolar macrophage	8 studies	46% ± 14%	Explore
monocyte	5 studies	28% ± 11%	Explore
dendritic cell	5 studies	24% ± 13%	Explore
hepatocyte	5 studies	47% ± 17%	Explore
mononuclear phagocyte	4 studies	35% ± 11%	Explore
tissue-resident macrophage	3 studies	53% ± 9%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	4 studies	30% ± 19%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	96%	3565.78	2549 / 2642	100%	55.77	703 / 705
liver	100%	17003.70	226 / 226	93%	48.07	379 / 406
intestine	99%	4585.74	955 / 966	91%	19.81	480 / 527
lung	100%	9574.04	578 / 578	86%	23.35	997 / 1155
breast	98%	3654.34	451 / 459	86%	15.63	959 / 1118
thymus	98%	3188.40	641 / 653	78%	10.78	473 / 605
pancreas	88%	1872.20	290 / 328	87%	20.80	155 / 178
stomach	72%	1384.68	257 / 359	96%	23.00	274 / 286
kidney	82%	2423.92	73 / 89	85%	26.84	768 / 901
esophagus	95%	2571.43	1379 / 1445	68%	11.51	124 / 183
bladder	100%	3092.00	21 / 21	59%	12.29	299 / 504
adrenal gland	100%	6755.41	257 / 258	51%	6.64	117 / 230
prostate	92%	2037.49	225 / 245	50%	4.90	251 / 502
uterus	95%	2483.71	162 / 170	45%	5.95	207 / 459
ovary	75%	1637.85	135 / 180	63%	10.18	271 / 430
skin	43%	685.98	779 / 1809	71%	14.22	333 / 472
adipose	99%	5933.42	1189 / 1204	0%	0	0 / 0
spleen	98%	10261.34	236 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	93%	27.94	27 / 29
heart	86%	1740.39	741 / 861	0%	0	0 / 0
blood vessel	82%	3058.47	1101 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	67%	12.40	30 / 45
eye	0%	0	0 / 0	28%	2.88	22 / 80
muscle	18%	219.82	142 / 803	0%	0	0 / 0
peripheral blood	5%	89.84	44 / 929	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0015721	Biological process	bile acid and bile salt transport
GO_0006811	Biological process	monoatomic ion transport
GO_0043252	Biological process	sodium-independent organic anion transport
GO_0006805	Biological process	xenobiotic metabolic process
GO_0015732	Biological process	prostaglandin transport
GO_0042167	Biological process	heme catabolic process
GO_0015711	Biological process	organic anion transport
GO_0055085	Biological process	transmembrane transport
GO_0150104	Biological process	transport across blood-brain barrier
GO_0016324	Cellular component	apical plasma membrane
GO_0009925	Cellular component	basal plasma membrane
GO_0005886	Cellular component	plasma membrane
GO_0016323	Cellular component	basolateral plasma membrane
GO_0015132	Molecular function	prostaglandin transmembrane transporter activity
GO_0015125	Molecular function	bile acid transmembrane transporter activity
GO_0008514	Molecular function	organic anion transmembrane transporter activity
GO_0015347	Molecular function	sodium-independent organic anion transmembrane transporter activity
GO_0022857	Molecular function	transmembrane transporter activity

IV. Literature review

[source]

Gene name	SLCO2B1
Protein name	Solute carrier organic anion transporter family member 2B1 Solute carrier organic anion transporter family member 2B1 (Organic anion transporter B) (OATP-B) (Organic anion transporter polypeptide-related protein 2) (OATP-RP2) (OATPRP2) (Organic anion transporting polypeptide 2B1) (OATP2B1) (Solute carrier family 21 member 9) Solute carrier organic anion transporter family, member 2B1 Solute carrier organic anion transporter family member
Synonyms	OATP2B1 KIAA0880 OATPB SLC21A9
Description	FUNCTION: Mediates the Na(+)-independent transport of steroid sulfate conjugates and other specific organic anions . Responsible for the transport of estrone 3-sulfate (E1S) through the basal membrane of syncytiotrophoblast, highlighting a potential role in the placental absorption of fetal-derived sulfated steroids including the steroid hormone precursor dehydroepiandrosterone sulfate (DHEA-S) . Also facilitates the uptake of sulfated steroids at the basal/sinusoidal membrane of hepatocytes, therefore accounting for the major part of organic anions clearance of liver . Mediates the intestinal uptake of sulfated steroids . Mediates the uptake of the neurosteroids DHEA-S and pregnenolone sulfate (PregS) into the endothelial cells of the blood-brain barrier as the first step to enter the brain . Also plays a role in the reuptake of neuropeptides such as substance P/TAC1 and vasoactive intestinal peptide/VIP released from retinal neurons . May act as a heme transporter that promotes cellular iron availability via heme oxygenase/HMOX2 and independently of TFRC . Also transports heme by-product coproporphyrin III (CPIII), and may be involved in their hepatic disposition . Mediates the uptake of other substrates such as prostaglandins D2 (PGD2), E1 (PGE1) and E2 (PGE2), taurocholate, L-thyroxine, leukotriene C4 and thromboxane B2 . May contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). Shows a pH-sensitive substrate specificity which may be ascribed to the protonation state of the binding site and leads to a stimulation of substrate transport in an acidic microenvironment . The exact transport mechanism has not been yet deciphered but most likely involves an anion exchange, coupling the cellular uptake of organic substrate with the efflux of an anionic compound . Hydrogencarbonate/HCO3(-) acts as a probable counteranion that exchanges for organic anions . Cytoplasmic glutamate may also act as counteranion in the placenta . An inwardly directed proton gradient has also been proposed as the driving force of E1S uptake with a (H(+):E1S) stoichiometry of (1:1) . .; FUNCTION: [Isoform 3]: Has estrone 3-sulfate (E1S) transport activity comparable with the full-length isoform 1. .
Accessions	E9PIU9 E9PRW4 ENST00000525845.5 ENST00000526839.1 E9PN87 ENST00000534186.5 ENST00000532236.5 C7BWB7 O94956 A0A1B0GX35 ENST00000534004.5 C7BWB6 ENST00000531713.5 A0A0A0MTF1 E9PI53 H0YE11 ENST00000428359.6 [O94956-3] ENST00000525650.5 [O94956-4] ENST00000527180.5 ENST00000525650.5 ENST00000289575.10 [O94956-1] ENST00000454962.6 [O94956-2] ENST00000530556.5

SLCO2B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review