I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 5 studies | 26% ± 7% | |
| ciliated cell | 3 studies | 30% ± 12% | |
| type II pneumocyte | 3 studies | 19% ± 3% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| type I pneumocyte | 5 studies | 26% ± 7% | |
| ciliated cell | 3 studies | 30% ± 12% | |
| type II pneumocyte | 3 studies | 19% ± 3% |
Insufficient scRNA-seq data for expression of SLC9C1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 99% | 59.25 | 648 / 653 | 11% | 0.22 | 69 / 605 |
| pancreas | 100% | 64.38 | 328 / 328 | 10% | 0.33 | 18 / 178 |
| kidney | 93% | 23.94 | 83 / 89 | 12% | 0.23 | 110 / 901 |
| lung | 88% | 24.31 | 506 / 578 | 9% | 0.39 | 104 / 1155 |
| heart | 90% | 55.10 | 772 / 861 | 0% | 0 | 0 / 0 |
| stomach | 78% | 33.86 | 281 / 359 | 7% | 0.48 | 19 / 286 |
| breast | 66% | 16.97 | 302 / 459 | 14% | 0.41 | 156 / 1118 |
| skin | 73% | 57.99 | 1329 / 1809 | 2% | 0.06 | 9 / 472 |
| esophagus | 43% | 9.00 | 624 / 1445 | 32% | 0.64 | 58 / 183 |
| prostate | 73% | 12.18 | 178 / 245 | 1% | 0.02 | 5 / 502 |
| bladder | 57% | 10.76 | 12 / 21 | 11% | 0.32 | 53 / 504 |
| intestine | 60% | 13.75 | 584 / 966 | 7% | 0.12 | 35 / 527 |
| blood vessel | 59% | 9.92 | 788 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 49% | 12.77 | 586 / 1204 | 0% | 0 | 0 / 0 |
| uterus | 35% | 4.32 | 59 / 170 | 4% | 0.08 | 19 / 459 |
| ovary | 23% | 2.67 | 42 / 180 | 0% | 0 | 0 / 430 |
| adrenal gland | 18% | 1.89 | 47 / 258 | 0% | 0 | 0 / 230 |
| spleen | 17% | 1.98 | 40 / 241 | 0% | 0 | 0 / 0 |
| muscle | 14% | 1.96 | 113 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 9% | 2.26 | 84 / 929 | 0% | 0 | 0 / 0 |
| liver | 1% | 0.19 | 3 / 226 | 1% | 0.02 | 5 / 406 |
| brain | 2% | 0.30 | 66 / 2642 | 0% | 0 | 0 / 705 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0098719 | Biological process | sodium ion import across plasma membrane |
| GO_0051453 | Biological process | regulation of intracellular pH |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0030317 | Biological process | flagellated sperm motility |
| GO_0030154 | Biological process | cell differentiation |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0031514 | Cellular component | motile cilium |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005216 | Molecular function | monoatomic ion channel activity |
| GO_0015385 | Molecular function | sodium:proton antiporter activity |
| GO_0015386 | Molecular function | potassium:proton antiporter activity |
| Gene name | SLC9C1 |
| Protein name | Sodium/hydrogen exchanger 10 (Solute carrier family 9 member C1) Solute carrier family 9 member C1 (Na(+)/H(+) exchanger 10) (NHE-10) (Sodium/hydrogen exchanger 10) (Solute carrier family 9 member 10) (Sperm-specific Na(+)/H(+) exchanger) (sNHE) |
| Synonyms | SLC9A10 |
| Description | FUNCTION: Sperm-specific solute carrier involved in intracellular pH regulation of spermatozoa. Required for sperm motility and fertility. Involved in sperm cell hyperactivation, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for the expression and bicarbonate regulation of the soluble adenylyl cyclase (sAC) (By similarity). . |
| Accessions | ENST00000647463.1 [Q4G0N8-2] ENST00000642787.1 ENST00000486574.5 ENST00000305815.10 [Q4G0N8-1] C9J3M6 ENST00000642317.2 [Q4G0N8-1] F8WCJ0 ENST00000471295.1 ENST00000487372.5 [Q4G0N8-2] ENST00000644496.1 Q4G0N8 |
