SLC9A8 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006811Biological processmonoatomic ion transport
GO_0051453Biological processregulation of intracellular pH
GO_0035725Biological processsodium ion transmembrane transport
GO_1905526Biological processregulation of Golgi lumen acidification
GO_0001675Biological processacrosome assembly
GO_0071805Biological processpotassium ion transmembrane transport
GO_1902600Biological processproton transmembrane transport
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0016324Cellular componentapical plasma membrane
GO_0000139Cellular componentGolgi membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0032585Cellular componentmultivesicular body membrane
GO_0015385Molecular functionsodium:proton antiporter activity
GO_0015386Molecular functionpotassium:proton antiporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC9A8
Protein nameSodium/hydrogen exchanger 8 (Na(+)/H(+) exchanger 8) (NHE-8) (Solute carrier family 9 member 8)
SynonymsKIAA0939
NHE8
DescriptionFUNCTION: Na(+)/H(+) antiporter. Mediates the electoneutral exchange of intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry . Acts as an Na(+)/H(+) exchanger in the trans-Golgi. Contributes to the regulation of pH regulation of Golgi apparatus, and consequently, in protein trafficking and endosomal morphology . In germ cells, plays a crucial role in acrosome biogenesis and sperm development, probably by playing a role in the fusion of the Golgi-derived vesicles that form the acrosomal cap (By similarity). Can also be active at the cell surface of specialized cells. In the small intestine, at the cell membrane, plays a major physiological role in transepithelial absorption of Na(+) and regulates intracellular pH homeostasis of intestinal epithelial cells . Acts as an important regulator of mucosal integrity in the intestine and in the stomach, could mediate the pH fluctuation necessary for mucin exocytosis or assist membrane trafficking of other proteins (By similarity). Plays a role in photoreceptor survival and in the maintenance of intracellular pH homeostasis in retinal pigment epithelium (RPE cells) (By similarity). .

AccessionsENST00000417961.5 [Q9Y2E8-2]
Q9Y2E8
ENST00000361573.3 [Q9Y2E8-1]