SLC7A11 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC7A11 at tissue level.

III. Associated gene sets

GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0034775Biological processglutathione transmembrane transport
GO_0070527Biological processplatelet aggregation
GO_0090461Biological processintracellular glutamate homeostasis
GO_0015813Biological processL-glutamate transmembrane transport
GO_0060173Biological processlimb development
GO_0110076Biological processnegative regulation of ferroptosis
GO_0098712Biological processL-glutamate import across plasma membrane
GO_0014070Biological processresponse to organic cyclic compound
GO_0021756Biological processstriatum development
GO_0051223Biological processregulation of protein transport
GO_0008542Biological processvisual learning
GO_1903786Biological processregulation of glutathione biosynthetic process
GO_0050807Biological processregulation of synapse organization
GO_0021591Biological processventricular system development
GO_0034599Biological processcellular response to oxidative stress
GO_0048021Biological processregulation of melanin biosynthetic process
GO_0051775Biological processresponse to redox state
GO_1901494Biological processregulation of cysteine metabolic process
GO_0035094Biological processresponse to nicotine
GO_0140924Biological processL-kynurenine transmembrane transport
GO_0003333Biological processamino acid transmembrane transport
GO_1900407Biological processregulation of cellular response to oxidative stress
GO_0030534Biological processadult behavior
GO_2000211Biological processregulation of glutamate metabolic process
GO_0015811Biological processL-cystine transport
GO_0140206Biological processdipeptide import across plasma membrane
GO_0009636Biological processresponse to toxic substance
GO_0070306Biological processlens fiber cell differentiation
GO_1904717Biological processregulation of AMPA glutamate receptor clustering
GO_0033029Biological processregulation of neutrophil apoptotic process
GO_0042127Biological processregulation of cell population proliferation
GO_0006749Biological processglutathione metabolic process
GO_0048286Biological processlung alveolus development
GO_0031526Cellular componentbrush border membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031528Cellular componentmicrovillus membrane
GO_0009986Cellular componentcell surface
GO_0097449Cellular componentastrocyte projection
GO_0045177Cellular componentapical part of cell
GO_0015179Molecular functionL-amino acid transmembrane transporter activity
GO_0140926Molecular functionL-kynurenine transmembrane transporter activity
GO_0015327Molecular functioncystine:glutamate antiporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC7A11
Protein nameBasigin
Uncharacterized protein SLC7A11
Cystine/glutamate transporter (Amino acid transport system xc-) (Calcium channel blocker resistance protein CCBR1) (Solute carrier family 7 member 11) (xCT)
Solute carrier family 7 member 11
Synonyms
DescriptionFUNCTION: Heterodimer with SLC3A2, that functions as an antiporter by mediating the exchange of extracellular anionic L-cystine and intracellular L-glutamate across the cellular plasma membrane . Provides L-cystine for the maintenance of the redox balance between extracellular L-cystine and L-cysteine and for the maintenance of the intracellular levels of glutathione that is essential for cells protection from oxidative stress (By similarity). The transport is sodium-independent, electroneutral with a stoichiometry of 1:1, and is drove by the high intracellular concentration of L-glutamate and the intracellular reduction of L-cystine . In addition, mediates the import of L-kynurenine leading to anti-ferroptotic signaling propagation required to maintain L-cystine and glutathione homeostasis . Moreover, mediates N-acetyl-L-cysteine uptake into the placenta leading to subsequently down-regulation of pathways associated with oxidative stress, inflammation and apoptosis . In vitro can also transport L-aspartate . May participate in astrocyte and meningeal cell proliferation during development and can provide neuroprotection by promoting glutathione synthesis and delivery from non-neuronal cells such as astrocytes and meningeal cells to immature neurons (By similarity). Controls the production of pheomelanin pigment directly (By similarity). .

AccessionsENST00000280612.9
A0A346RDT0
A0A346RDX9
A0A346RCR1
A0A346RDX8
A0A346RDY0
A0A346RDU2
A0A346REH8
Q4W5A5
ENST00000509248.1
Q9UPY5
A0A346REM6
H0Y9F9
A0A346RDX7
A0A346RCP0