Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 42% ± 20% | |
| oligodendrocyte precursor cell | 12 studies | 49% ± 20% | |
| oligodendrocyte | 11 studies | 36% ± 13% | |
| GABAergic neuron | 10 studies | 52% ± 26% | |
| interneuron | 6 studies | 59% ± 23% | |
| pericyte | 5 studies | 56% ± 22% | |
| amacrine cell | 5 studies | 29% ± 8% | |
| endothelial cell | 5 studies | 46% ± 16% | |
| GABAergic interneuron | 3 studies | 55% ± 18% | |
| smooth muscle cell | 3 studies | 73% ± 18% | |
| hepatocyte | 3 studies | 32% ± 20% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 12 studies | 32% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 13391.57 | 2638 / 2642 | 99% | 40.82 | 700 / 705 |
| liver | 88% | 6062.51 | 198 / 226 | 89% | 18.18 | 363 / 406 |
| kidney | 7% | 114.94 | 6 / 89 | 40% | 1.12 | 364 / 901 |
| esophagus | 28% | 636.70 | 399 / 1445 | 5% | 0.12 | 9 / 183 |
| adrenal gland | 0% | 23.24 | 1 / 258 | 31% | 1.14 | 72 / 230 |
| blood vessel | 28% | 600.28 | 368 / 1335 | 0% | 0 | 0 / 0 |
| thymus | 0% | 1.92 | 1 / 653 | 18% | 2.62 | 106 / 605 |
| lung | 8% | 118.32 | 47 / 578 | 7% | 0.15 | 80 / 1155 |
| heart | 14% | 201.06 | 120 / 861 | 0% | 0 | 0 / 0 |
| prostate | 13% | 204.93 | 31 / 245 | 1% | 0.01 | 3 / 502 |
| pancreas | 0% | 0 | 0 / 328 | 12% | 0.19 | 22 / 178 |
| uterus | 10% | 138.61 | 17 / 170 | 0% | 0.01 | 2 / 459 |
| ovary | 8% | 128.03 | 14 / 180 | 1% | 0.02 | 4 / 430 |
| eye | 0% | 0 | 0 / 0 | 6% | 0.31 | 5 / 80 |
| adipose | 5% | 74.92 | 65 / 1204 | 0% | 0 | 0 / 0 |
| breast | 1% | 15.57 | 6 / 459 | 4% | 0.06 | 45 / 1118 |
| skin | 2% | 25.57 | 33 / 1809 | 2% | 0.06 | 11 / 472 |
| intestine | 1% | 16.89 | 13 / 966 | 2% | 0.05 | 12 / 527 |
| bladder | 0% | 0 | 0 / 21 | 4% | 0.08 | 18 / 504 |
| stomach | 0% | 0 | 0 / 359 | 2% | 0.03 | 7 / 286 |
| spleen | 0% | 5.39 | 1 / 241 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| muscle | 0% | 0 | 0 / 803 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0032355 | Biological process | response to estradiol |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0010288 | Biological process | response to lead ion |
| GO_0014074 | Biological process | response to purine-containing compound |
| GO_0008306 | Biological process | associative learning |
| GO_0032229 | Biological process | negative regulation of synaptic transmission, GABAergic |
| GO_0042220 | Biological process | response to cocaine |
| GO_0009744 | Biological process | response to sucrose |
| GO_1902476 | Biological process | chloride transmembrane transport |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0098658 | Biological process | inorganic anion import across plasma membrane |
| GO_0098719 | Biological process | sodium ion import across plasma membrane |
| GO_0007613 | Biological process | memory |
| GO_0006865 | Biological process | amino acid transport |
| GO_0014054 | Biological process | positive regulation of gamma-aminobutyric acid secretion |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0050808 | Biological process | synapse organization |
| GO_0051939 | Biological process | gamma-aminobutyric acid import |
| GO_0051592 | Biological process | response to calcium ion |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_0051936 | Biological process | gamma-aminobutyric acid reuptake |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0042734 | Cellular component | presynaptic membrane |
| GO_0098982 | Cellular component | GABA-ergic synapse |
| GO_0009986 | Cellular component | cell surface |
| GO_0045211 | Cellular component | postsynaptic membrane |
| GO_0030424 | Cellular component | axon |
| GO_0015378 | Molecular function | sodium:chloride symporter activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005332 | Molecular function | gamma-aminobutyric acid:sodium:chloride symporter activity |
| GO_0015185 | Molecular function | gamma-aminobutyric acid transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SLC6A1 |
| Protein name | Solute carrier family 6 member 1 Transporter Solute carrier family 6 member 1 (cDNA FLJ57116, highly similar to Sodium- and chloride-dependent GABA transporter 1) Sodium- and chloride-dependent GABA transporter 1 (GAT-1) (Solute carrier family 6 member 1) |
| Synonyms | GAT1 GABATR GABT1 |
| Description | FUNCTION: Mediates transport of gamma-aminobutyric acid (GABA) together with sodium and chloride and is responsible for the reuptake of GABA from the synapse . The translocation of GABA, however, may also occur in the reverse direction leading to the release of GABA (By similarity). The direction and magnitude of GABA transport is a consequence of the prevailing thermodynamic conditions, determined by membrane potential and the intracellular and extracellular concentrations of Na(+), Cl(-) and GABA (By similarity). Can also mediate sodium- and chloride-dependent transport of hypotaurine but to a much lower extent as compared to GABA (By similarity). . |
| Accessions | ENST00000646088.1 ENST00000643498.1 ENST00000644803.1 C9J5P8 ENST00000646487.1 ENST00000642767.1 ENST00000645054.1 ENST00000647384.1 ENST00000647194.1 A0A2R8Y3X2 ENST00000643396.1 ENST00000644175.1 ENST00000645974.1 ENST00000642515.1 ENST00000287766.10 A0A2R8YF74 ENST00000642820.1 ENST00000642735.1 ENST00000646570.1 ENST00000643326.1 ENST00000646022.1 ENST00000645592.1 ENST00000645985.1 A0A2R8Y867 A0A8V8TMZ9 ENST00000645776.1 A0A2R8YFI0 P30531 ENST00000644314.1 A0A2R8Y4I3 ENST00000698198.1 ENST00000642201.1 ENST00000645029.1 A0A2R8YEF0 ENST00000460480.2 A0A2R8YDD5 B7Z3C5 ENST00000646060.1 ENST00000642639.1 A0A2R8YCM3 ENST00000646924.1 ENST00000645281.1 A0A2R8Y495 ENST00000646072.1 ENST00000645575.1 ENST00000425938.6 ENST00000646702.1 |
