SLC5A3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC5A3 at tissue level.

III. Associated gene sets

GO_0015798Biological processmyo-inositol transport
GO_1904659Biological processglucose transmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_1903428Biological processpositive regulation of reactive oxygen species biosynthetic process
GO_0043576Biological processregulation of respiratory gaseous exchange
GO_1904679Biological processmyo-inositol import across plasma membrane
GO_0043085Biological processpositive regulation of catalytic activity
GO_0015791Biological processpolyol transmembrane transport
GO_1905477Biological processpositive regulation of protein localization to membrane
GO_0007422Biological processperipheral nervous system development
GO_0015750Biological processpentose transmembrane transport
GO_0015756Biological processfucose transmembrane transport
GO_0006020Biological processinositol metabolic process
GO_0035725Biological processsodium ion transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0016020Cellular componentmembrane
GO_0008076Cellular componentvoltage-gated potassium channel complex
GO_0016323Cellular componentbasolateral plasma membrane
GO_0015166Molecular functionpolyol transmembrane transporter activity
GO_0015150Molecular functionfucose transmembrane transporter activity
GO_0005412Molecular functionglucose:sodium symporter activity
GO_0015459Molecular functionpotassium channel regulator activity
GO_0044325Molecular functiontransmembrane transporter binding
GO_0005365Molecular functionmyo-inositol transmembrane transporter activity
GO_0005367Molecular functionmyo-inositol:sodium symporter activity
GO_0005515Molecular functionprotein binding
GO_0015146Molecular functionpentose transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC5A3
Protein nameSodium/myo-inositol cotransporter (Na(+)/myo-inositol cotransporter) (Sodium/myo-inositol transporter 1) (SMIT1) (Solute carrier family 5 member 3)
Synonyms
DescriptionFUNCTION: Electrogenic Na(+)-coupled sugar symporter that actively transports myo-inositol and its stereoisomer scyllo-inositol across the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1 (By similarity). Maintains myo-inositol concentration gradient that defines cell volume and fluid balance during osmotic stress, in particular in the fetoplacental unit and central nervous system (By similarity). Forms coregulatory complexes with voltage-gated K(+) ion channels, allosterically altering ion selectivity, voltage dependence and gating kinetics of the channel. In turn, K(+) efflux through the channel forms a local electrical gradient that modulates electrogenic Na(+)-coupled myo-inositol influx through the transporter . Associates with KCNQ1-KCNE2 channel in the apical membrane of choroid plexus epithelium and regulates the myo-inositol gradient between blood and cerebrospinal fluid with an impact on neuron excitability (By similarity). Associates with KCNQ2-KCNQ3 channel altering ion selectivity, increasing Na(+) and Cs(+) permeation relative to K(+) permeation . Provides myo-inositol precursor for biosynthesis of phosphoinositides such as PI(4,5)P2, thus indirectly affecting the activity of phosphoinositide-dependent ion channels and Ca(2+) signaling upon osmotic stress . .

AccessionsENST00000381151.5
P53794