SLC5A1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC5A1 at tissue level.

III. Associated gene sets

GO_0000017Biological processalpha-glucoside transport
GO_0015798Biological processmyo-inositol transport
GO_1904659Biological processglucose transmembrane transport
GO_0098708Biological processglucose import across plasma membrane
GO_0150104Biological processtransport across blood-brain barrier
GO_0015757Biological processgalactose transmembrane transport
GO_0035623Biological processrenal glucose absorption
GO_1902476Biological processchloride transmembrane transport
GO_0006814Biological processsodium ion transport
GO_0001951Biological processintestinal D-glucose absorption
GO_0098719Biological processsodium ion import across plasma membrane
GO_0015750Biological processpentose transmembrane transport
GO_0015756Biological processfucose transmembrane transport
GO_0106001Biological processintestinal hexose absorption
GO_0035377Biological processtransepithelial water transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0005769Cellular componentearly endosome
GO_0043229Cellular componentintracellular organelle
GO_0070062Cellular componentextracellular exosome
GO_0097708Cellular componentintracellular vesicle
GO_0005354Molecular functiongalactose transmembrane transporter activity
GO_0015371Molecular functiongalactose:sodium symporter activity
GO_0015150Molecular functionfucose transmembrane transporter activity
GO_0055056Molecular functionD-glucose transmembrane transporter activity
GO_0005412Molecular functionglucose:sodium symporter activity
GO_0015151Molecular functionalpha-glucoside transmembrane transporter activity
GO_0005367Molecular functionmyo-inositol:sodium symporter activity
GO_0005372Molecular functionwater transmembrane transporter activity
GO_0005355Molecular functionglucose transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0015146Molecular functionpentose transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC5A1
Protein nameSodium/glucose cotransporter 1 (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)
Sodium/glucose cotransporter 1 (Na(+)/glucose cotransporter 1) (High affinity sodium-glucose cotransporter) (Solute carrier family 5 member 1)
SynonymsNAGT
SGLT1
DescriptionFUNCTION: Electrogenic Na(+)-coupled sugar simporter that actively transports D-glucose or D-galactose at the plasma membrane, with a Na(+) to sugar coupling ratio of 2:1. Transporter activity is driven by a transmembrane Na(+) electrochemical gradient set by the Na(+)/K(+) pump . Has a primary role in the transport of dietary monosaccharides from enterocytes to blood. Responsible for the absorption of D-glucose or D-galactose across the apical brush-border membrane of enterocytes, whereas basolateral exit is provided by GLUT2. Additionally, functions as a D-glucose sensor in enteroendocrine cells, triggering the secretion of the incretins GCG and GIP that control food intake and energy homeostasis (By similarity). Together with SGLT2, functions in reabsorption of D-glucose from glomerular filtrate, playing a nonredundant role in the S3 segment of the proximal tubules (By similarity). Transports D-glucose into endometrial epithelial cells, controlling glycogen synthesis and nutritional support for the embryo as well as the decidual transformation of endometrium prior to conception . Acts as a water channel enabling passive water transport across the plasma membrane in response to the osmotic gradient created upon sugar and Na(+) uptake. Has high water conductivity, comparable to aquaporins, and therefore is expected to play an important role in transepithelial water permeability, especially in the small intestine. .

AccessionsENST00000543737.2 [P13866-2]
P13866
ENST00000266088.9 [P13866-1]
A4QPH0