SLC46A2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC46A2 at tissue level.

III. Associated gene sets

GO_0043029Biological processT cell homeostasis
GO_0070233Biological processnegative regulation of T cell apoptotic process
GO_0045580Biological processregulation of T cell differentiation
GO_0048538Biological processthymus development
GO_0140361Biological processcyclic-GMP-AMP transmembrane import across plasma membrane
GO_0055085Biological processtransmembrane transport
GO_0045087Biological processinnate immune response
GO_0070430Biological processpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0009986Cellular componentcell surface
GO_0010008Cellular componentendosome membrane
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0015293Molecular functionsymporter activity
GO_0140360Molecular functioncyclic-GMP-AMP transmembrane transporter activity
GO_0022857Molecular functiontransmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC46A2
Protein nameSolute carrier family 46 member 2
Solute carrier family 46 member 2 (Thymic stromal cotransporter homolog)
SynonymsTSCOT
DescriptionFUNCTION: Proton-coupled transporter that delivers pathogen-associated or danger-associated molecular patterns to cytosolic pattern recognition receptors as part of the innate immune response to microbes or tissue injury . Has selectivity toward muropeptides that contain the amino acid diaminopimelic acid (DAP-type peptidoglycan muropeptides) including Tri-DAP and tracheal toxin (TCT), common in Gram-negative bacteria and Gram-positive bacilli. In the context of immune recognition of skin microbiota, shuttles bacterial muropeptides across the endolysosomal membranes into the cytosol for recognition by NOD1, triggering MYD88-dependent secretion of IL1A and neutrophil recruitment in a pyroptosis-type inflammatory process . To a lesser extent and redundantly, transports muramyl dipeptides derived from most bacterial proteoglycans, eliciting NOD2 receptor activation and downstream inflammatory responses . Postulated to function as a dominant importer of cyclic GMP-AMP dinucleotides (cGAMPs) in monocyte and macrophage cell lineages. Selectively imports cGAMPs derived from pathogenic bacteria such as 3'3'-cGAMP thus providing for differential immune recognition of pathogenic versus commensal bacteria. During tumorigenesis may transport extracellular tumor-derived 2'3'-cGAMP across the plasma membrane of M1-polarized macrophages to activate the anti-tumoral stimulator of interferon genes (STING) pathway . The transport mechanism, its electrogenicity and stoichiometry remain to be elucidated (Probable). .

AccessionsQ9BY10
S4R3Y2
ENST00000374228.5
ENST00000491462.2