SLC39A14 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071333Biological processcellular response to glucose stimulus
GO_0071577Biological processzinc ion transmembrane transport
GO_0032869Biological processcellular response to insulin stimulus
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0051344Biological processnegative regulation of cyclic-nucleotide phosphodiesterase activity
GO_0002062Biological processchondrocyte differentiation
GO_0034755Biological processiron ion transmembrane transport
GO_0098739Biological processimport across plasma membrane
GO_0071421Biological processmanganese ion transmembrane transport
GO_0098662Biological processinorganic cation transmembrane transport
GO_0045745Biological processpositive regulation of G protein-coupled receptor signaling pathway
GO_0010817Biological processregulation of hormone levels
GO_0008286Biological processinsulin receptor signaling pathway
GO_0055071Biological processmanganese ion homeostasis
GO_0006094Biological processgluconeogenesis
GO_0006882Biological processintracellular zinc ion homeostasis
GO_0030003Biological processintracellular monoatomic cation homeostasis
GO_0071578Biological processzinc ion import across plasma membrane
GO_0033212Biological processiron import into cell
GO_0015701Biological processbicarbonate transport
GO_0070574Biological processcadmium ion transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005385Molecular functionzinc ion transmembrane transporter activity
GO_0015093Molecular functionferrous iron transmembrane transporter activity
GO_0015086Molecular functioncadmium ion transmembrane transporter activity
GO_0140410Molecular functionmonoatomic cation:bicarbonate symporter activity
GO_0005384Molecular functionmanganese ion transmembrane transporter activity
GO_0005381Molecular functioniron ion transmembrane transporter activity
GO_0015296Molecular functionmonoatomic anion:monoatomic cation symporter activity

IV. Literature review

[source]
Gene nameSLC39A14
Protein nameSolute carrier family 39 member 14
Metal cation symporter ZIP14 (LIV-1 subfamily of ZIP zinc transporter 4) (LZT-Hs4) (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14) (ZIP-14)
Metal cation symporter ZIP14 (Solute carrier family 39 member 14) (Zrt- and Irt-like protein 14)
SynonymsZIP14
hCG_15998
KIAA0062
DescriptionFUNCTION: Electroneutral transporter of the plasma membrane mediating the cellular uptake of the divalent metal cations zinc, manganese and iron that are important for tissue homeostasis, metabolism, development and immunity . Functions as an energy-dependent symporter, transporting through the membranes an electroneutral complex composed of a divalent metal cation and two bicarbonate anions (By similarity). Beside these endogenous cellular substrates, can also import cadmium a non-essential metal which is cytotoxic and carcinogenic (By similarity). Controls the cellular uptake by the intestinal epithelium of systemic zinc, which is in turn required to maintain tight junctions and the intestinal permeability (By similarity). Modifies the activity of zinc-dependent phosphodiesterases, thereby indirectly regulating G protein-coupled receptor signaling pathways important for gluconeogenesis and chondrocyte differentiation (By similarity). Regulates insulin receptor signaling, glucose uptake, glycogen synthesis and gluconeogenesis in hepatocytes through the zinc-dependent intracellular catabolism of insulin . Through zinc cellular uptake also plays a role in the adaptation of cells to endoplasmic reticulum stress (By similarity). Major manganese transporter of the basolateral membrane of intestinal epithelial cells, it plays a central role in manganese systemic homeostasis through intestinal manganese uptake . Also involved in manganese extracellular uptake by cells of the blood-brain barrier . May also play a role in manganese and zinc homeostasis participating in their elimination from the blood through the hepatobiliary excretion (By similarity). Also functions in the extracellular uptake of free iron. May also function intracellularly and mediate the transport from endosomes to cytosol of iron endocytosed by transferrin . Plays a role in innate immunity by regulating the expression of cytokines by activated macrophages . .

AccessionsENST00000517370.1
E5RFZ8
A0A0S2Z534
E5RGA7
ENST00000519960.5
E5RFF5
ENST00000520832.1
E5RFT1
ENST00000524285.1
ENST00000522881.2
E5RJG5
ENST00000381237.6 [Q15043-1]
A0A0S2Z5Z7
Q15043
ENST00000289952.9 [Q15043-1]
ENST00000359741.10 [Q15043-3]
ENST00000520644.1
A0A0S2Z5C8
ENST00000240095.10 [Q15043-2]
E5RIP4
A0A0S2Z5B1
E5RJ40
ENST00000517552.1