SLC30A1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC30A1 at tissue level.

III. Associated gene sets

GO_1902897Biological processregulation of postsynaptic density protein 95 clustering
GO_0071577Biological processzinc ion transmembrane transport
GO_0001701Biological processin utero embryonic development
GO_0062111Biological processzinc ion import into organelle
GO_0061003Biological processpositive regulation of dendritic spine morphogenesis
GO_0071584Biological processnegative regulation of zinc ion transmembrane import
GO_0006874Biological processintracellular calcium ion homeostasis
GO_0090281Biological processnegative regulation of calcium ion import
GO_0046929Biological processnegative regulation of neurotransmitter secretion
GO_0070509Biological processcalcium ion import
GO_0071585Biological processdetoxification of cadmium ion
GO_0006882Biological processintracellular zinc ion homeostasis
GO_0042742Biological processdefense response to bacterium
GO_0010312Biological processdetoxification of zinc ion
GO_0006829Biological processzinc ion transport
GO_0140882Biological processzinc export across plasma membrane
GO_0070574Biological processcadmium ion transmembrane transport
GO_0098839Cellular componentpostsynaptic density membrane
GO_0098685Cellular componentSchaffer collateral - CA1 synapse
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005794Cellular componentGolgi apparatus
GO_0030425Cellular componentdendrite
GO_0030315Cellular componentT-tubule
GO_0005783Cellular componentendoplasmic reticulum
GO_0099573Cellular componentglutamatergic postsynaptic density
GO_0005737Cellular componentcytoplasm
GO_0099092Cellular componentpostsynaptic density, intracellular component
GO_0031965Cellular componentnuclear membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0005385Molecular functionzinc ion transmembrane transporter activity
GO_0140826Molecular functionzinc:proton antiporter activity
GO_0046872Molecular functionmetal ion binding
GO_0019855Molecular functioncalcium channel inhibitor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC30A1
Protein nameProton-coupled zinc antiporter SLC30A1 (Solute carrier family 30 member 1) (Zinc transporter 1)
Putative zinc transporter 1
SynonymsZNT1
DescriptionFUNCTION: Zinc ion:proton antiporter that could function at the plasma membrane mediating zinc efflux from cells against its electrochemical gradient protecting them from intracellular zinc accumulation and toxicity . Alternatively, could prevent the transport to the plasma membrane of CACNB2, the L-type calcium channels regulatory subunit, through a yet to be defined mechanism. By modulating the expression of these channels at the plasma membrane, could prevent calcium and zinc influx into cells. By the same mechanism, could also prevent L-type calcium channels-mediated heavy metal influx into cells (By similarity). In some cells, could also function as a zinc ion:proton antiporter mediating zinc entry into the lumen of cytoplasmic vesicles. In macrophages, can increase zinc ions concentration into the lumen of cytoplasmic vesicles containing engulfed bacteria and could help inactivate them . .

AccessionsQ96KD7
Q9Y6M5
ENST00000367001.5