SLC26A6 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of SLC26A6 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC26A6 at tissue level.

III. Associated gene sets

GO_0044849Biological processestrous cycle
GO_0015724Biological processformate transport
GO_0006821Biological processchloride transport
GO_0046724Biological processoxalic acid secretion
GO_0019532Biological processoxalate transport
GO_0070633Biological processtransepithelial transport
GO_0006811Biological processmonoatomic ion transport
GO_0048240Biological processsperm capacitation
GO_0051649Biological processestablishment of localization in cell
GO_0042045Biological processepithelial fluid transport
GO_2001150Biological processpositive regulation of dipeptide transmembrane transport
GO_0071320Biological processcellular response to cAMP
GO_0008272Biological processsulfate transport
GO_1902476Biological processchloride transmembrane transport
GO_0030321Biological processtransepithelial chloride transport
GO_0050892Biological processintestinal absorption
GO_1902358Biological processsulfate transmembrane transport
GO_0051453Biological processregulation of intracellular pH
GO_0051454Biological processintracellular pH elevation
GO_0015701Biological processbicarbonate transport
GO_0015797Biological processmannitol transmembrane transport
GO_0071332Biological processcellular response to fructose stimulus
GO_0071346Biological processcellular response to type II interferon
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0012506Cellular componentvesicle membrane
GO_0016020Cellular componentmembrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0034707Cellular componentchloride channel complex
GO_0097225Cellular componentsperm midpiece
GO_0031982Cellular componentvesicle
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0019531Molecular functionoxalate transmembrane transporter activity
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0015116Molecular functionsulfate transmembrane transporter activity
GO_0016740Molecular functiontransferase activity
GO_0030165Molecular functionPDZ domain binding
GO_0015106Molecular functionbicarbonate transmembrane transporter activity
GO_0008271Molecular functionsecondary active sulfate transmembrane transporter activity
GO_0015108Molecular functionchloride transmembrane transporter activity
GO_0140900Molecular functionchloride:bicarbonate antiporter activity
GO_0005452Molecular functionsolute:inorganic anion antiporter activity
GO_0005254Molecular functionchloride channel activity
GO_0015499Molecular functionformate transmembrane transporter activity

IV. Literature review

[source]
Gene nameSLC26A6
Protein nameSolute carrier family 26 member 6 (Anion exchange transporter) (Pendrin-like protein 1) (Pendrin-L1)
Solute carrier family 26 member 6
Solute carrier family 26 member 6 (Solute carrier family 26, member 6, isoform CRA_i)
Solute carrier family 26, member 6
SynonymshCG_1999608
DescriptionFUNCTION: Apical membrane anion-exchanger with wide epithelial distribution that plays a role as a component of the pH buffering system for maintaining acid-base homeostasis. Acts as a versatile DIDS-sensitive inorganic and organic anion transporter that mediates the uptake of monovalent anions like chloride, bicarbonate, formate and hydroxyl ion and divalent anions like sulfate and oxalate. Functions in multiple exchange modes involving pairs of these anions, which include chloride-bicarbonate, chloride-oxalate, oxalate-formate, oxalate-sulfate and chloride-formate exchange. Apical membrane chloride-bicarbonate exchanger that mediates luminal chloride absorption and bicarbonate secretion by the small intestinal brush border membrane and contributes to intracellular pH regulation in the duodenal upper villous epithelium during proton-coupled peptide absorption, possibly by providing a bicarbonate import pathway. Mediates also intestinal chloride absorption and oxalate secretion, thereby preventing hyperoxaluria and calcium oxalate urolithiasis. Transepithelial oxalate secretion, chloride-formate, chloride-oxalate and chloride-bicarbonate transport activities in the duodenum are inhibited by PKC activation in a calcium-independent manner. The apical membrane chloride-bicarbonate exchanger provides also a major route for fluid and bicarbonate secretion into the proximal tubules of the kidney as well as into the proximal part of the interlobular pancreatic ductal tree, where it mediates electrogenic chloride-bicarbonate exchange with a chloride-bicarbonate stoichiometry of 1:2, and hence will dilute and alkalinize protein-rich acinar secretion. Mediates also the transcellular sulfate absorption and oxalate secretion across the apical membrane in the duodenum and the formate ion efflux at the apical brush border of cells in the proximal tubules of kidney. Plays a role in sperm capacitation by increasing intracellular pH. .; FUNCTION: [Isoform 4]: Apical membrane chloride-bicarbonate exchanger. Its association with carbonic anhydrase CA2 forms a bicarbonate transport metabolon; hence maximizes the local concentration of bicarbonate at the transporter site. .

AccessionsENST00000383733.7 [Q9BXS9-2]
Q9BXS9
ENST00000414944.1
H7BZJ6
ENST00000421649.5
Q86YZ4
ENST00000358747.10
A0A0C4DFT5
ENST00000426599.1
C9JKR6
ENST00000395550.7 [Q9BXS9-1]
ENST00000444531.5
H7C291
ENST00000455886.6 [Q9BXS9-7]
G3XAC1
H7BZB1
ENST00000337000.12
ENST00000420764.6 [Q9BXS9-3]
C9J6Y3
ENST00000431213.5
ENST00000431739.5
ENST00000307364.10
H7BZ36
F8W9I8