I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 28% ± 12% | |
| astrocyte | 3 studies | 28% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 5 studies | 28% ± 12% | |
| astrocyte | 3 studies | 28% ± 7% |
Insufficient scRNA-seq data for expression of SLC22A5 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 2081.49 | 245 / 245 | 100% | 11.54 | 502 / 502 |
| kidney | 100% | 4294.03 | 89 / 89 | 99% | 25.37 | 896 / 901 |
| intestine | 100% | 1772.75 | 966 / 966 | 95% | 5.09 | 503 / 527 |
| thymus | 100% | 1382.53 | 652 / 653 | 95% | 5.70 | 577 / 605 |
| esophagus | 100% | 831.32 | 1443 / 1445 | 95% | 4.49 | 174 / 183 |
| brain | 99% | 1241.09 | 2614 / 2642 | 95% | 5.40 | 670 / 705 |
| pancreas | 100% | 1076.09 | 328 / 328 | 94% | 4.51 | 167 / 178 |
| stomach | 100% | 1039.89 | 358 / 359 | 94% | 4.97 | 269 / 286 |
| breast | 99% | 1221.89 | 456 / 459 | 94% | 10.41 | 1054 / 1118 |
| adrenal gland | 100% | 1224.61 | 258 / 258 | 91% | 4.13 | 210 / 230 |
| bladder | 100% | 1057.24 | 21 / 21 | 90% | 4.79 | 452 / 504 |
| lung | 99% | 825.72 | 572 / 578 | 88% | 3.63 | 1020 / 1155 |
| uterus | 100% | 1180.74 | 170 / 170 | 82% | 3.75 | 375 / 459 |
| ovary | 100% | 1240.78 | 180 / 180 | 82% | 3.46 | 351 / 430 |
| liver | 100% | 897.97 | 226 / 226 | 68% | 2.94 | 275 / 406 |
| skin | 89% | 1145.28 | 1613 / 1809 | 57% | 1.99 | 270 / 472 |
| muscle | 100% | 6142.97 | 803 / 803 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 3.96 | 1 / 1 |
| spleen | 100% | 635.02 | 240 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 99% | 868.32 | 1320 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 99% | 881.24 | 1186 / 1204 | 0% | 0 | 0 / 0 |
| heart | 96% | 1384.14 | 826 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 80% | 2.94 | 36 / 45 |
| eye | 0% | 0 | 0 / 0 | 45% | 1.41 | 36 / 80 |
| peripheral blood | 21% | 73.92 | 196 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 14% | 0.35 | 4 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0060731 | Biological process | positive regulation of intestinal epithelial structure maintenance |
| GO_0015697 | Biological process | quaternary ammonium group transport |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_1902270 | Biological process | (R)-carnitine transmembrane transport |
| GO_1990961 | Biological process | xenobiotic detoxification by transmembrane export across the plasma membrane |
| GO_0034612 | Biological process | response to tumor necrosis factor |
| GO_0034341 | Biological process | response to type II interferon |
| GO_0070715 | Biological process | sodium-dependent organic cation transport |
| GO_0009609 | Biological process | response to symbiotic bacterium |
| GO_1902603 | Biological process | carnitine transmembrane transport |
| GO_0006814 | Biological process | sodium ion transport |
| GO_1900749 | Biological process | (R)-carnitine transport |
| GO_0015879 | Biological process | carnitine transport |
| GO_0031526 | Cellular component | brush border membrane |
| GO_0016324 | Cellular component | apical plasma membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0009925 | Cellular component | basal plasma membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0015651 | Molecular function | quaternary ammonium group transmembrane transporter activity |
| GO_0015293 | Molecular function | symporter activity |
| GO_0015226 | Molecular function | carnitine transmembrane transporter activity |
| GO_0042910 | Molecular function | xenobiotic transmembrane transporter activity |
| GO_0030165 | Molecular function | PDZ domain binding |
| GO_0015199 | Molecular function | amino-acid betaine transmembrane transporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_1901235 | Molecular function | (R)-carnitine transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SLC22A5 |
| Protein name | Solute carrier family 22 member 5 Organic cation/carnitine transporter 2 (High-affinity sodium-dependent carnitine cotransporter) (Solute carrier family 22 member 5) |
| Synonyms | OCTN2 |
| Description | FUNCTION: Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine . Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Relative uptake activity ratio of carnitine to TEA is 11.3 . In intestinal epithelia, transports the quorum-sensing pentapeptide CSF (competence and sporulation factor) from Bacillus Subtilis wich induces cytoprotective heat shock proteins contributing to intestinal homeostasis . May also contribute to regulate the transport of organic compounds in testis across the blood-testis-barrier (Probable). .; FUNCTION: [Isoform 3]: Retained in the ER, unable to perform carnitine uptake. . |
| Accessions | H7BZF0 O76082 A0A8I5KXW0 A0A8I5KYG6 H7BZC0 A0A8I5KTN6 A0A8I5KUV4 ENST00000692413.1 ENST00000689271.1 ENST00000415928.6 A0A8I5KUR7 F8WCC9 A0A8I5QL37 ENST00000690900.1 A0A8I5KW68 H7C1R8 ENST00000448810.6 ENST00000693308.1 ENST00000437841.6 ENST00000686757.1 ENST00000447841.5 ENST00000692825.1 ENST00000692355.1 ENST00000245407.8 [O76082-1] ENST00000435065.7 [O76082-3] |
