SLC22A3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015844Biological processmonoamine transport
GO_0015695Biological processorganic cation transport
GO_0015697Biological processquaternary ammonium group transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0090494Biological processdopamine uptake
GO_0006811Biological processmonoatomic ion transport
GO_1903711Biological processspermidine transmembrane transport
GO_1990748Biological processcellular detoxification
GO_0032098Biological processregulation of appetite
GO_0048241Biological processepinephrine transport
GO_0015872Biological processdopamine transport
GO_0042908Biological processxenobiotic transport
GO_0051620Biological processnorepinephrine uptake
GO_0001692Biological processhistamine metabolic process
GO_0006837Biological processserotonin transport
GO_0015711Biological processorganic anion transport
GO_0006836Biological processneurotransmitter transport
GO_0015874Biological processnorepinephrine transport
GO_0051610Biological processserotonin uptake
GO_0051608Biological processhistamine transport
GO_0072530Biological processpurine-containing compound transmembrane transport
GO_0015718Biological processmonocarboxylic acid transport
GO_0051625Biological processepinephrine uptake
GO_0051615Biological processhistamine uptake
GO_0015848Biological processspermidine transport
GO_0016324Cellular componentapical plasma membrane
GO_0098793Cellular componentpresynapse
GO_0005886Cellular componentplasma membrane
GO_0012505Cellular componentendomembrane system
GO_0016020Cellular componentmembrane
GO_0031966Cellular componentmitochondrial membrane
GO_0043025Cellular componentneuronal cell body
GO_0005640Cellular componentnuclear outer membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0008514Molecular functionorganic anion transmembrane transporter activity
GO_0015101Molecular functionorganic cation transmembrane transporter activity
GO_0015651Molecular functionquaternary ammonium group transmembrane transporter activity
GO_0005326Molecular functionneurotransmitter transmembrane transporter activity
GO_0008504Molecular functionmonoamine transmembrane transporter activity
GO_0015606Molecular functionspermidine transmembrane transporter activity
GO_0019534Molecular functiontoxin transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC22A3
Protein nameExtraneuronal monoamine transporter (EMT)
Solute carrier family 22 member 3 (Extraneuronal monoamine transporter) (EMT) (Organic cation transporter 3) (OCT3)
Organic cation transporter 3
SynonymsEMTH
OCT3
DescriptionFUNCTION: Electrogenic voltage-dependent transporter that mediates the transport of a variety of organic cations such as endogenous bioactive amines, cationic drugs and xenobiotics . Cation cellular uptake or release is driven by the electrochemical potential, i.e. membrane potential and concentration gradient . Functions as a Na(+)- and Cl(-)-independent, bidirectional uniporter . Implicated in monoamine neurotransmitters uptake such as dopamine, adrenaline/epinephrine, noradrenaline/norepinephrine, histamine, serotonin and tyramine, thereby supporting a role in homeostatic regulation of aminergic neurotransmission in the brain . Transports dopaminergic neuromodulators cyclo(his-pro) and salsolinol with low efficiency . May be involved in the uptake and disposition of cationic compounds by renal clearance from the blood flow . May contribute to regulate the transport of cationic compounds in testis across the blood-testis-barrier (Probable). Mediates the transport of polyamine spermidine and putrescine (By similarity). Mediates the bidirectional transport of polyamine agmatine . Also transports guanidine . May also mediate intracellular transport of organic cations, thereby playing a role in amine metabolism and intracellular signaling (By similarity). .

AccessionsQ96KH7
O75751
Q9NQC0
ENST00000275300.3