SLC20A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006811Biological processmonoatomic ion transport
GO_0046718Biological processsymbiont entry into host cell
GO_0035435Biological processphosphate ion transmembrane transport
GO_0030501Biological processpositive regulation of bone mineralization
GO_0035725Biological processsodium ion transmembrane transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005315Molecular functionphosphate transmembrane transporter activity
GO_0038023Molecular functionsignaling receptor activity
GO_0001618Molecular functionvirus receptor activity
GO_0005436Molecular functionsodium:phosphate symporter activity

IV. Literature review

[source]
Gene nameSLC20A2
Protein nameSodium-dependent phosphate transporter 2 (Phosphate transporter 2) (Solute carrier family 20 member 2)
Solute carrier family 20 member 2
Sodium-dependent phosphate transporter 2 (Gibbon ape leukemia virus receptor 2) (GLVR-2) (Phosphate transporter 2) (PiT-2) (Pit2) (hPit2) (Solute carrier family 20 member 2)
SynonymsGLVR2
PIT2
DescriptionFUNCTION: Sodium-phosphate symporter which preferentially transports the monovalent form of phosphate with a stoichiometry of two sodium ions per phosphate ion . Plays a critical role in the determination of bone quality and strength by providing phosphate for bone mineralization (By similarity). Required to maintain normal cerebrospinal fluid phosphate levels (By similarity). Mediates phosphate-induced calcification of vascular smooth muscle cells (VCMCs) and can functionally compensate for loss of SLC20A1 in VCMCs (By similarity). .; FUNCTION: (Microbial infection) Functions as a retroviral receptor and confers human cells susceptibility to infection to amphotropic murine leukemia virus (A-MuLV), 10A1 murine leukemia virus (10A1 MLV) and some feline leukemia virus subgroup B (FeLV-B) variants. .

AccessionsE5RGG8
Q08357
E5RIX1
ENST00000517366.1
ENST00000520262.6
ENST00000520179.5
ENST00000518384.1
E5RJW9
ENST00000518717.1
ENST00000342228.7
E5RGM8
ENST00000524211.1
ENST00000522707.1
E5RGJ6