SLC18A3 | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC18A3 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
intestine	76%	89.54	734 / 966	3%	0.17	16 / 527
esophagus	41%	33.62	589 / 1445	14%	1.60	26 / 183
brain	35%	103.88	921 / 2642	13%	1.45	95 / 705
stomach	40%	80.64	145 / 359	5%	0.20	15 / 286
adrenal gland	8%	3.10	20 / 258	31%	5.24	72 / 230
ovary	0%	0	0 / 180	29%	1.89	126 / 430
thymus	0%	0.05	1 / 653	22%	1.75	132 / 605
pancreas	4%	1.54	13 / 328	15%	0.32	26 / 178
prostate	4%	7.32	11 / 245	14%	0.65	70 / 502
tonsil	0%	0	0 / 0	18%	1.52	8 / 45
lung	0%	0.06	1 / 578	17%	1.71	198 / 1155
kidney	0%	0	0 / 89	11%	2.57	102 / 901
uterus	0%	0	0 / 170	11%	1.30	50 / 459
heart	5%	3.04	40 / 861	0%	0	0 / 0
bladder	0%	0	0 / 21	4%	1.27	21 / 504
skin	1%	1.25	16 / 1809	2%	0.06	9 / 472
eye	0%	0	0 / 0	3%	0.04	2 / 80
breast	0%	0.06	1 / 459	1%	0.06	9 / 1118
liver	0%	0	0 / 226	1%	0.03	4 / 406
blood vessel	1%	0.35	7 / 1335	0%	0	0 / 0
adipose	0%	0.05	2 / 1204	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
lymph node	0%	0	0 / 0	0%	0	0 / 29
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
peripheral blood	0%	0	0 / 929	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
spleen	0%	0	0 / 241	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_1904398	Biological process	positive regulation of neuromuscular junction development
GO_0007268	Biological process	chemical synaptic transmission
GO_1900273	Biological process	positive regulation of long-term synaptic potentiation
GO_0006836	Biological process	neurotransmitter transport
GO_0051610	Biological process	serotonin uptake
GO_0051630	Biological process	acetylcholine uptake
GO_1902600	Biological process	proton transmembrane transport
GO_0014057	Biological process	positive regulation of acetylcholine secretion, neurotransmission
GO_0060201	Cellular component	clathrin-sculpted acetylcholine transport vesicle membrane
GO_0005886	Cellular component	plasma membrane
GO_0030122	Cellular component	AP-2 adaptor complex
GO_0043195	Cellular component	terminal bouton
GO_0030672	Cellular component	synaptic vesicle membrane
GO_0030121	Cellular component	AP-1 adaptor complex
GO_0030669	Cellular component	clathrin-coated endocytic vesicle membrane
GO_0015311	Molecular function	monoamine:proton antiporter activity
GO_0005278	Molecular function	acetylcholine:proton antiporter activity
GO_0005277	Molecular function	acetylcholine transmembrane transporter activity
GO_0005515	Molecular function	protein binding

Gene name	SLC18A3
Protein name	Vesicular acetylcholine transporter (VAChT) (Solute carrier family 18 member 3)
Synonyms	VACHT
Description	FUNCTION: Electrogenic antiporter that exchanges one cholinergic neurotransmitter, acetylcholine or choline, with two intravesicular protons across the membrane of synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to store neurotransmitters inside the vesicles prior to their release via exocytosis (By similarity). Determines cholinergic vesicular quantal size at presynaptic nerve terminals in developing neuro-muscular junctions with an impact on motor neuron differentiation and innervation pattern (By similarity). Part of forebrain cholinergic system, regulates hippocampal synapse transmissions that underlie spatial memory formation (By similarity). Can transport serotonin. .
Accessions	Q16572 ENST00000374115.5

SLC18A3 report