I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mast cell | 31 studies | 59% ± 17% | |
| granulocyte | 3 studies | 48% ± 25% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| mast cell | 31 studies | 59% ± 17% | |
| granulocyte | 3 studies | 48% ± 25% |
Insufficient scRNA-seq data for expression of SLC18A2 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 99% | 254.40 | 573 / 578 | 32% | 0.75 | 371 / 1155 |
| pancreas | 91% | 125.77 | 297 / 328 | 39% | 1.12 | 70 / 178 |
| prostate | 96% | 178.89 | 235 / 245 | 31% | 1.03 | 157 / 502 |
| stomach | 99% | 204.59 | 356 / 359 | 27% | 0.82 | 76 / 286 |
| esophagus | 91% | 132.45 | 1320 / 1445 | 23% | 0.40 | 42 / 183 |
| bladder | 100% | 133.71 | 21 / 21 | 9% | 0.16 | 46 / 504 |
| breast | 81% | 58.00 | 371 / 459 | 23% | 0.64 | 262 / 1118 |
| adrenal gland | 38% | 104.11 | 98 / 258 | 65% | 50.87 | 150 / 230 |
| intestine | 88% | 91.56 | 850 / 966 | 15% | 0.66 | 78 / 527 |
| uterus | 91% | 141.82 | 155 / 170 | 7% | 0.13 | 30 / 459 |
| ovary | 96% | 324.79 | 173 / 180 | 0% | 0.02 | 2 / 430 |
| adipose | 90% | 98.54 | 1085 / 1204 | 0% | 0 | 0 / 0 |
| skin | 72% | 136.76 | 1298 / 1809 | 1% | 0.03 | 4 / 472 |
| kidney | 30% | 21.98 | 27 / 89 | 23% | 0.97 | 207 / 901 |
| blood vessel | 44% | 24.57 | 592 / 1335 | 0% | 0 | 0 / 0 |
| liver | 24% | 8.67 | 55 / 226 | 2% | 0.04 | 7 / 406 |
| heart | 18% | 6.43 | 155 / 861 | 0% | 0 | 0 / 0 |
| thymus | 12% | 4.42 | 78 / 653 | 6% | 0.14 | 34 / 605 |
| peripheral blood | 16% | 6.13 | 151 / 929 | 0% | 0 | 0 / 0 |
| spleen | 15% | 4.79 | 36 / 241 | 0% | 0 | 0 / 0 |
| brain | 12% | 72.12 | 325 / 2642 | 1% | 0.03 | 4 / 705 |
| muscle | 12% | 4.04 | 95 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 11% | 0.15 | 5 / 45 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 80 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0015842 | Biological process | aminergic neurotransmitter loading into synaptic vesicle |
| GO_0015844 | Biological process | monoamine transport |
| GO_0009791 | Biological process | post-embryonic development |
| GO_0002553 | Biological process | histamine secretion by mast cell |
| GO_0042137 | Biological process | sequestering of neurotransmitter |
| GO_1903427 | Biological process | negative regulation of reactive oxygen species biosynthetic process |
| GO_0015872 | Biological process | dopamine transport |
| GO_0007268 | Biological process | chemical synaptic transmission |
| GO_0006836 | Biological process | neurotransmitter transport |
| GO_0051610 | Biological process | serotonin uptake |
| GO_0098700 | Biological process | neurotransmitter loading into synaptic vesicle |
| GO_0001975 | Biological process | response to amphetamine |
| GO_0099123 | Biological process | somato-dendritic dopamine secretion |
| GO_0002552 | Biological process | serotonin secretion by mast cell |
| GO_0009636 | Biological process | response to toxic substance |
| GO_0007626 | Biological process | locomotory behavior |
| GO_0051615 | Biological process | histamine uptake |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0030667 | Cellular component | secretory granule membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0005813 | Cellular component | centrosome |
| GO_0043195 | Cellular component | terminal bouton |
| GO_0030672 | Cellular component | synaptic vesicle membrane |
| GO_0098691 | Cellular component | dopaminergic synapse |
| GO_0030425 | Cellular component | dendrite |
| GO_0008021 | Cellular component | synaptic vesicle |
| GO_0070083 | Cellular component | clathrin-sculpted monoamine transport vesicle membrane |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0030424 | Cellular component | axon |
| GO_0005335 | Molecular function | serotonin:sodium:chloride symporter activity |
| GO_0015311 | Molecular function | monoamine:proton antiporter activity |
| GO_0008504 | Molecular function | monoamine transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SLC18A2 |
| Protein name | Synaptic vesicular amine transporter (Monoamine transporter) (Solute carrier family 18 member 2) (Vesicular amine transporter 2) (VAT2) |
| Synonyms | VMAT2 SVMT |
| Description | FUNCTION: Electrogenic antiporter that exchanges one cationic monoamine with two intravesicular protons across the membrane of secretory and synaptic vesicles. Uses the electrochemical proton gradient established by the V-type proton-pump ATPase to accumulate high concentrations of monoamines inside the vesicles prior to their release via exocytosis. Transports a variety of catecholamines such as dopamine, adrenaline and noradrenaline, histamine, and indolamines such as serotonin . Regulates the transvesicular monoaminergic gradient that determines the quantal size. Mediates somatodendritic dopamine release in hippocampal neurons, likely as part of a regulated secretory pathway that integrates retrograde synaptic signals (By similarity). Acts as a primary transporter for striatal dopamine loading ensuring impulse-dependent release of dopamine at the synaptic cleft (By similarity). Responsible for histamine and serotonin storage and subsequent corelease from mast cell granules (By similarity). . |
| Accessions | Q05940 ENST00000644641.2 [Q05940-1] |
