SLC15A4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015835Biological processpeptidoglycan transport
GO_0045087Biological processinnate immune response
GO_0006811Biological processmonoatomic ion transport
GO_0033023Biological processmast cell homeostasis
GO_0034157Biological processpositive regulation of toll-like receptor 7 signaling pathway
GO_0045089Biological processpositive regulation of innate immune response
GO_0089708Biological processL-histidine transmembrane export from vacuole
GO_0034165Biological processpositive regulation of toll-like receptor 9 signaling pathway
GO_0070434Biological processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0015833Biological processpeptide transport
GO_0070424Biological processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0070430Biological processpositive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO_0015031Biological processprotein transport
GO_0140206Biological processdipeptide import across plasma membrane
GO_0015817Biological processhistidine transport
GO_0048302Biological processregulation of isotype switching to IgG isotypes
GO_1902600Biological processproton transmembrane transport
GO_0034161Biological processpositive regulation of toll-like receptor 8 signaling pathway
GO_0035579Cellular componentspecific granule membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031901Cellular componentearly endosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0036020Cellular componentendolysosome membrane
GO_0071916Molecular functiondipeptide transmembrane transporter activity
GO_0005290Molecular functionL-histidine transmembrane transporter activity
GO_0015333Molecular functionpeptide:proton symporter activity
GO_0015647Molecular functionpeptidoglycan transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC15A4
Protein nameSolute carrier family 15 member 4
Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)
SynonymsPTR4
PHT1
FP12591
DescriptionFUNCTION: Proton-coupled amino-acid transporter that mediates the transmembrane transport of L-histidine and some di- and tripeptides from inside the lysosome to the cytosol, and plays a key role in innate immune response . Able to transport a variety of di- and tripeptides, including carnosine and some peptidoglycans . Transporter activity is pH-dependent and maximized in the acidic lysosomal environment (By similarity). Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand, and L-alanyl-gamma-D-glutamyl-meso-2,6-diaminoheptanedioate (tri-DAP), the NOD1 ligand . Required for TLR7, TLR8 and TLR9-mediated type I interferon (IFN-I) productions in plasmacytoid dendritic cells (pDCs) . Independently of its transporter activity, also promotes the recruitment of innate immune adapter TASL to endolysosome downstream of TLR7, TLR8 and TLR9: TASL recruitment leads to the specific recruitment and activation of IRF5 . Required for isotype class switch recombination to IgG2c isotype in response to TLR9 stimulation (By similarity). Required for mast cell secretory-granule homeostasis by limiting mast cell functions and inflammatory responses (By similarity). .

AccessionsENST00000376744.8
ENST00000376740.8
Q8N697
B6ZDF2
H7BYB7
ENST00000266771.10 [Q8N697-1]