SLC15A3 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SLC15A3 at tissue level.

III. Associated gene sets

GO_0006811Biological processmonoatomic ion transport
GO_1902600Biological processproton transmembrane transport
GO_0015031Biological processprotein transport
GO_0140206Biological processdipeptide import across plasma membrane
GO_0015835Biological processpeptidoglycan transport
GO_0070434Biological processpositive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0015833Biological processpeptide transport
GO_0045087Biological processinnate immune response
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0005765Cellular componentlysosomal membrane
GO_0071916Molecular functiondipeptide transmembrane transporter activity
GO_0015647Molecular functionpeptidoglycan transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0015333Molecular functionpeptide:proton symporter activity

IV. Literature review

[source]
Gene nameSLC15A3
Protein nameSolute carrier family 15 member 3 (Solute carrier family 15, member 3, isoform CRA_a)
SLC15A3 protein
Solute carrier family 15 member 3 (Osteoclast transporter) (Peptide transporter 3) (Peptide/histidine transporter 2) (hPHT2)
Solute carrier family 15 member 3
SynonymsPHT2
OCTP
PTR3
hCG_40399
DescriptionFUNCTION: Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine . Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). .

AccessionsENST00000681951.1
A0A7P0T8H0
ENST00000537307.1
H0YG40
F5GZ36
Q8IY34
Q05CH4
F5H1C8
ENST00000681275.1
A0A7P0TAX8
H0YFC1
ENST00000679573.1
ENST00000538739.2
A0A7P0Z4G8
ENST00000681882.1
ENST00000536491.2
A0A7P0T8B5
ENST00000227880.8
ENST00000536784.6
F5H251
ENST00000541505.5