Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 25 studies | 22% ± 8% | |
| classical monocyte | 11 studies | 24% ± 11% | |
| alveolar macrophage | 7 studies | 21% ± 6% | |
| myeloid cell | 7 studies | 28% ± 10% | |
| non-classical monocyte | 5 studies | 32% ± 12% | |
| monocyte | 3 studies | 28% ± 3% | |
| conventional dendritic cell | 3 studies | 26% ± 12% | |
| Mueller cell | 3 studies | 25% ± 1% | |
| dendritic cell | 3 studies | 26% ± 12% | |
| glial cell | 3 studies | 32% ± 23% |
Insufficient scRNA-seq data for expression of SLC15A3 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| breast | 100% | 1332.47 | 458 / 459 | 96% | 18.85 | 1077 / 1118 |
| lung | 100% | 3773.48 | 578 / 578 | 95% | 20.32 | 1100 / 1155 |
| ovary | 100% | 1848.08 | 180 / 180 | 94% | 26.25 | 403 / 430 |
| uterus | 100% | 1367.06 | 170 / 170 | 93% | 22.87 | 425 / 459 |
| intestine | 100% | 2030.09 | 962 / 966 | 85% | 12.84 | 447 / 527 |
| esophagus | 93% | 1338.39 | 1348 / 1445 | 90% | 13.50 | 165 / 183 |
| stomach | 94% | 1069.71 | 338 / 359 | 88% | 14.76 | 252 / 286 |
| kidney | 91% | 898.00 | 81 / 89 | 91% | 18.76 | 819 / 901 |
| bladder | 100% | 1038.24 | 21 / 21 | 81% | 15.51 | 407 / 504 |
| thymus | 95% | 822.45 | 621 / 653 | 79% | 9.52 | 478 / 605 |
| prostate | 99% | 1283.62 | 242 / 245 | 70% | 5.37 | 350 / 502 |
| skin | 68% | 458.71 | 1234 / 1809 | 88% | 25.99 | 414 / 472 |
| adrenal gland | 95% | 861.23 | 245 / 258 | 54% | 5.16 | 124 / 230 |
| liver | 68% | 455.05 | 153 / 226 | 76% | 8.58 | 309 / 406 |
| brain | 51% | 361.45 | 1349 / 2642 | 87% | 13.30 | 614 / 705 |
| pancreas | 18% | 104.39 | 58 / 328 | 93% | 21.09 | 165 / 178 |
| adipose | 100% | 1915.99 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 66.78 | 29 / 29 |
| peripheral blood | 100% | 5101.61 | 929 / 929 | 0% | 0 | 0 / 0 |
| spleen | 100% | 4994.32 | 241 / 241 | 0% | 0 | 0 / 0 |
| heart | 98% | 935.09 | 843 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 33.83 | 44 / 45 |
| blood vessel | 93% | 1072.09 | 1238 / 1335 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 79% | 15.05 | 63 / 80 |
| muscle | 15% | 71.22 | 123 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006811 | Biological process | monoatomic ion transport |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0015031 | Biological process | protein transport |
| GO_0140206 | Biological process | dipeptide import across plasma membrane |
| GO_0015835 | Biological process | peptidoglycan transport |
| GO_0070434 | Biological process | positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway |
| GO_0015833 | Biological process | peptide transport |
| GO_0045087 | Biological process | innate immune response |
| GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0005765 | Cellular component | lysosomal membrane |
| GO_0071916 | Molecular function | dipeptide transmembrane transporter activity |
| GO_0015647 | Molecular function | peptidoglycan transmembrane transporter activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0015333 | Molecular function | peptide:proton symporter activity |
| Gene name | SLC15A3 |
| Protein name | Solute carrier family 15 member 3 (Solute carrier family 15, member 3, isoform CRA_a) SLC15A3 protein Solute carrier family 15 member 3 (Osteoclast transporter) (Peptide transporter 3) (Peptide/histidine transporter 2) (hPHT2) Solute carrier family 15 member 3 |
| Synonyms | PHT2 OCTP PTR3 hCG_40399 |
| Description | FUNCTION: Proton-coupled amino-acid transporter that transports free histidine and certain di- and tripeptides, and is involved in innate immune response (By similarity). Also able to transport carnosine . Involved in the detection of microbial pathogens by toll-like receptors (TLRs) and NOD-like receptors (NLRs), probably by mediating transport of bacterial peptidoglycans across the endolysosomal membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand (By similarity). . |
| Accessions | ENST00000681951.1 A0A7P0T8H0 ENST00000537307.1 H0YG40 F5GZ36 Q8IY34 Q05CH4 F5H1C8 ENST00000681275.1 A0A7P0TAX8 H0YFC1 ENST00000679573.1 ENST00000538739.2 A0A7P0Z4G8 ENST00000681882.1 ENST00000536491.2 A0A7P0T8B5 ENST00000227880.8 ENST00000536784.6 F5H251 ENST00000541505.5 |
