SLC15A2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0015835Biological processpeptidoglycan transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0006811Biological processmonoatomic ion transport
GO_1990961Biological processxenobiotic detoxification by transmembrane export across the plasma membrane
GO_0042938Biological processdipeptide transport
GO_0140207Biological processtripeptide import across plasma membrane
GO_0140367Biological processantibacterial innate immune response
GO_0042908Biological processxenobiotic transport
GO_0070293Biological processrenal absorption
GO_0015833Biological processpeptide transport
GO_0070424Biological processregulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO_0015031Biological processprotein transport
GO_0140206Biological processdipeptide import across plasma membrane
GO_1902600Biological processproton transmembrane transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0071916Molecular functiondipeptide transmembrane transporter activity
GO_0015333Molecular functionpeptide:proton symporter activity
GO_0042937Molecular functiontripeptide transmembrane transporter activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSLC15A2
Protein nameSolute carrier family 15 member 2 (Kidney H(+)/peptide cotransporter) (Oligopeptide transporter, kidney isoform) (Peptide transporter 2)
Solute carrier family 15 member 2 (Peptide transporter 2)
SynonymsPEPT2
DescriptionFUNCTION: Proton-coupled amino-acid transporter that transports oligopeptides of 2 to 4 amino acids with a preference for dipeptides . Transports neutral and anionic dipeptides with a proton to peptide stoichiometry of 2:1 or 3:1 (By similarity). In kidney, involved in the absorption of circulating di- and tripeptides from the glomerular filtrate . Can also transport beta-lactam antibiotics, such as the aminocephalosporin cefadroxil, and other antiviral and anticancer drugs . Transports the dipeptide-like aminopeptidase inhibitor bestatin (By similarity). Also able to transport carnosine . Involved in innate immunity by promoting the detection of microbial pathogens by NOD-like receptors (NLRs) (By similarity). Mediates transport of bacterial peptidoglycans across the plasma membrane or, in macrophages, the phagosome membrane: catalyzes the transport of certain bacterial peptidoglycans, such as muramyl dipeptide (MDP), the NOD2 ligand . .

AccessionsENST00000295605.6 [Q16348-2]
ENST00000489711.6 [Q16348-1]
Q16348
ENST00000469013.1
C9IZ38
A0PJB0
Q86UE9