SKA2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0031110Biological processregulation of microtubule polymerization or depolymerization
GO_0051315Biological processattachment of mitotic spindle microtubules to kinetochore
GO_0051301Biological processcell division
GO_0000278Biological processmitotic cell cycle
GO_0007059Biological processchromosome segregation
GO_0000070Biological processmitotic sister chromatid segregation
GO_0000776Cellular componentkinetochore
GO_0000940Cellular componentouter kinetochore
GO_0005876Cellular componentspindle microtubule
GO_0005829Cellular componentcytosol
GO_0005515Molecular functionprotein binding
GO_0008017Molecular functionmicrotubule binding

IV. Literature review

[source]
Gene nameSKA2
Protein nameSpindle and kinetochore associated complex subunit 2
Spindle and kinetochore-associated protein 2 (Protein FAM33A)
Family with sequence similarity 33, member A, isoform CRA_c (Spindle and kinetochore associated complex subunit 2)
SynonymsFAM33A
hCG_2000185
DescriptionFUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation . Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint . The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies . The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner . In the complex, it is required for SKA1 localization . Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules . .

AccessionsQ8WVK7
J3QKN8
J3QS74
J3KRZ0
ENST00000330137.12 [Q8WVK7-1]
J3KSP0
ENST00000580541.1
J3KTC5
ENST00000583976.1
ENST00000578519.5
ENST00000584089.1
J3KRW9
ENST00000578105.1
ENST00000581068.5
ENST00000583380.5
J3QL03
ENST00000437036.6 [Q8WVK7-2]