Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| CD8-positive, alpha-beta T cell | 8 studies | 19% ± 4% | |
| fibroblast | 6 studies | 22% ± 5% | |
| endothelial cell | 6 studies | 24% ± 7% | |
| T cell | 6 studies | 23% ± 6% | |
| pericyte | 5 studies | 24% ± 6% | |
| natural killer cell | 5 studies | 24% ± 10% | |
| neuron | 5 studies | 27% ± 12% | |
| regulatory T cell | 5 studies | 17% ± 1% | |
| GABAergic neuron | 5 studies | 27% ± 6% | |
| astrocyte | 5 studies | 26% ± 4% | |
| oligodendrocyte precursor cell | 5 studies | 19% ± 4% | |
| oligodendrocyte | 5 studies | 19% ± 1% | |
| CD4-positive, alpha-beta T cell | 5 studies | 19% ± 5% | |
| plasmablast | 4 studies | 36% ± 18% | |
| conventional dendritic cell | 4 studies | 22% ± 5% | |
| hematopoietic precursor cell | 4 studies | 18% ± 3% | |
| myofibroblast cell | 4 studies | 20% ± 3% | |
| smooth muscle cell | 4 studies | 18% ± 1% | |
| epithelial cell | 4 studies | 36% ± 5% | |
| glutamatergic neuron | 4 studies | 29% ± 4% | |
| connective tissue cell | 3 studies | 26% ± 4% | |
| B cell | 3 studies | 27% ± 1% | |
| amacrine cell | 3 studies | 29% ± 7% | |
| retina horizontal cell | 3 studies | 29% ± 7% | |
| retinal cone cell | 3 studies | 39% ± 11% | |
| ciliated cell | 3 studies | 29% ± 3% | |
| erythrocyte | 3 studies | 29% ± 18% | |
| dendritic cell | 3 studies | 27% ± 5% | |
| transit amplifying cell | 3 studies | 34% ± 6% | |
| interneuron | 3 studies | 34% ± 12% | |
| effector CD8-positive, alpha-beta T cell | 3 studies | 21% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 1437.40 | 1445 / 1445 | 100% | 48.44 | 183 / 183 |
| ovary | 100% | 1096.48 | 180 / 180 | 100% | 49.89 | 430 / 430 |
| uterus | 100% | 1475.22 | 170 / 170 | 100% | 63.47 | 459 / 459 |
| brain | 100% | 2753.58 | 2641 / 2642 | 100% | 84.84 | 705 / 705 |
| thymus | 100% | 1413.91 | 653 / 653 | 100% | 39.30 | 603 / 605 |
| breast | 100% | 941.72 | 459 / 459 | 100% | 49.82 | 1114 / 1118 |
| prostate | 100% | 1299.78 | 245 / 245 | 100% | 24.52 | 500 / 502 |
| lung | 99% | 1089.31 | 573 / 578 | 100% | 41.87 | 1153 / 1155 |
| bladder | 100% | 1239.57 | 21 / 21 | 99% | 43.30 | 497 / 504 |
| stomach | 100% | 954.71 | 358 / 359 | 98% | 34.41 | 281 / 286 |
| intestine | 100% | 1269.95 | 965 / 966 | 97% | 33.63 | 513 / 527 |
| adrenal gland | 99% | 950.90 | 256 / 258 | 97% | 34.65 | 224 / 230 |
| skin | 99% | 1141.72 | 1782 / 1809 | 97% | 41.27 | 460 / 472 |
| kidney | 100% | 1103.03 | 89 / 89 | 96% | 24.44 | 864 / 901 |
| pancreas | 89% | 464.27 | 293 / 328 | 99% | 26.84 | 176 / 178 |
| liver | 93% | 519.88 | 211 / 226 | 91% | 19.62 | 369 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 39.43 | 29 / 29 |
| spleen | 100% | 966.38 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 58.25 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 22.45 | 1 / 1 |
| blood vessel | 100% | 1617.13 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| adipose | 100% | 1006.29 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| heart | 97% | 1104.12 | 832 / 861 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 88% | 18.04 | 70 / 80 |
| muscle | 77% | 350.85 | 620 / 803 | 0% | 0 | 0 / 0 |
| peripheral blood | 43% | 845.44 | 403 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0031110 | Biological process | regulation of microtubule polymerization or depolymerization |
| GO_0051315 | Biological process | attachment of mitotic spindle microtubules to kinetochore |
| GO_0051301 | Biological process | cell division |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0007059 | Biological process | chromosome segregation |
| GO_0000070 | Biological process | mitotic sister chromatid segregation |
| GO_0000776 | Cellular component | kinetochore |
| GO_0000940 | Cellular component | outer kinetochore |
| GO_0005876 | Cellular component | spindle microtubule |
| GO_0005829 | Cellular component | cytosol |
| GO_0005515 | Molecular function | protein binding |
| GO_0008017 | Molecular function | microtubule binding |
| Gene name | SKA2 |
| Protein name | Spindle and kinetochore associated complex subunit 2 Spindle and kinetochore-associated protein 2 (Protein FAM33A) Family with sequence similarity 33, member A, isoform CRA_c (Spindle and kinetochore associated complex subunit 2) |
| Synonyms | FAM33A hCG_2000185 |
| Description | FUNCTION: Component of the SKA1 complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation . Required for timely anaphase onset during mitosis, when chromosomes undergo bipolar attachment on spindle microtubules leading to silencing of the spindle checkpoint . The SKA1 complex is a direct component of the kinetochore-microtubule interface and directly associates with microtubules as oligomeric assemblies . The complex facilitates the processive movement of microspheres along a microtubule in a depolymerization-coupled manner . In the complex, it is required for SKA1 localization . Affinity for microtubules is synergistically enhanced in the presence of the ndc-80 complex and may allow the ndc-80 complex to track depolymerizing microtubules . . |
| Accessions | Q8WVK7 J3QKN8 J3QS74 J3KRZ0 ENST00000330137.12 [Q8WVK7-1] J3KSP0 ENST00000580541.1 J3KTC5 ENST00000583976.1 ENST00000578519.5 ENST00000584089.1 J3KRW9 ENST00000578105.1 ENST00000581068.5 ENST00000583380.5 J3QL03 ENST00000437036.6 [Q8WVK7-2] |