I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal cone cell | 3 studies | 52% ± 18% | |
| Mueller cell | 3 studies | 34% ± 2% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal cone cell | 3 studies | 52% ± 18% | |
| Mueller cell | 3 studies | 34% ± 2% |
Insufficient scRNA-seq data for expression of SIX6 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| muscle | 89% | 21.32 | 716 / 803 | 0% | 0 | 0 / 0 |
| prostate | 60% | 16.58 | 147 / 245 | 11% | 0.21 | 55 / 502 |
| brain | 12% | 31.20 | 326 / 2642 | 17% | 1.77 | 122 / 705 |
| eye | 0% | 0 | 0 / 0 | 18% | 0.98 | 14 / 80 |
| adrenal gland | 2% | 1.99 | 5 / 258 | 6% | 0.66 | 13 / 230 |
| skin | 1% | 0.81 | 19 / 1809 | 6% | 0.18 | 30 / 472 |
| thymus | 5% | 1.01 | 34 / 653 | 2% | 0.09 | 11 / 605 |
| adipose | 5% | 0.61 | 65 / 1204 | 0% | 0 | 0 / 0 |
| uterus | 2% | 0.17 | 3 / 170 | 2% | 0.08 | 7 / 459 |
| lung | 2% | 0.22 | 13 / 578 | 1% | 0.02 | 8 / 1155 |
| stomach | 3% | 1.79 | 9 / 359 | 0% | 0 | 0 / 286 |
| breast | 2% | 0.15 | 9 / 459 | 1% | 0.01 | 6 / 1118 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.23 | 1 / 45 |
| blood vessel | 2% | 0.28 | 24 / 1335 | 0% | 0 | 0 / 0 |
| liver | 2% | 0.35 | 4 / 226 | 0% | 0 | 0 / 406 |
| ovary | 2% | 0.13 | 3 / 180 | 0% | 0 | 0 / 430 |
| pancreas | 2% | 0.11 | 5 / 328 | 0% | 0 | 0 / 178 |
| intestine | 1% | 0.10 | 11 / 966 | 0% | 0.00 | 2 / 527 |
| esophagus | 1% | 0.34 | 21 / 1445 | 0% | 0 | 0 / 183 |
| kidney | 0% | 0 | 0 / 89 | 1% | 0.29 | 13 / 901 |
| spleen | 1% | 0.11 | 3 / 241 | 0% | 0 | 0 / 0 |
| heart | 1% | 0.10 | 8 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0.02 | 3 / 929 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 0% | 0.00 | 1 / 504 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0007601 | Biological process | visual perception |
| GO_0009887 | Biological process | animal organ morphogenesis |
| GO_0001654 | Biological process | eye development |
| GO_0006357 | Biological process | regulation of transcription by RNA polymerase II |
| GO_0000785 | Cellular component | chromatin |
| GO_0005667 | Cellular component | transcription regulator complex |
| GO_0005634 | Cellular component | nucleus |
| GO_1990837 | Molecular function | sequence-specific double-stranded DNA binding |
| GO_0000978 | Molecular function | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| GO_0000981 | Molecular function | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Gene name | SIX6 |
| Protein name | Sine oculis homeobox-like protein 6 Sine oculis homeobox protein 6 SIX6 protein Homeobox protein SIX6 (Homeodomain protein OPTX2) (Optic homeobox 2) (Sine oculis homeobox homolog 6) |
| Synonyms | SIX9 OPTX2 |
| Description | FUNCTION: May be involved in eye development. |
| Accessions | A0A127AXL1 A0A0H3W5R8 A0A1B3B2J1 A0A1B3B2M0 A0A1B3B2J6 Q6P051 A0A1B3B2K2 A0A0H3W5E5 Q5M8S8 ENST00000327720.6 A0A0H3W5J9 A0A0H3W5H1 O95475 |
