SIRPA report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050870Biological processpositive regulation of T cell activation
GO_0010468Biological processregulation of gene expression
GO_0032680Biological processregulation of tumor necrosis factor production
GO_0050766Biological processpositive regulation of phagocytosis
GO_0071650Biological processnegative regulation of chemokine (C-C motif) ligand 5 production
GO_0032649Biological processregulation of type II interferon production
GO_0045428Biological processregulation of nitric oxide biosynthetic process
GO_0032715Biological processnegative regulation of interleukin-6 production
GO_0070373Biological processnegative regulation of ERK1 and ERK2 cascade
GO_1900016Biological processnegative regulation of cytokine production involved in inflammatory response
GO_0045019Biological processnegative regulation of nitric oxide biosynthetic process
GO_0007155Biological processcell adhesion
GO_0034113Biological processheterotypic cell-cell adhesion
GO_0071347Biological processcellular response to interleukin-1
GO_0071346Biological processcellular response to type II interferon
GO_0001933Biological processnegative regulation of protein phosphorylation
GO_0050765Biological processnegative regulation of phagocytosis
GO_1903720Biological processnegative regulation of I-kappaB phosphorylation
GO_0050728Biological processnegative regulation of inflammatory response
GO_0032651Biological processregulation of interleukin-1 beta production
GO_0046329Biological processnegative regulation of JNK cascade
GO_0032688Biological processnegative regulation of interferon-beta production
GO_0071222Biological processcellular response to lipopolysaccharide
GO_0032675Biological processregulation of interleukin-6 production
GO_0032720Biological processnegative regulation of tumor necrosis factor production
GO_0071349Biological processcellular response to interleukin-12
GO_0071641Biological processnegative regulation of macrophage inflammatory protein 1 alpha production
GO_0016477Biological processcell migration
GO_0070301Biological processcellular response to hydrogen peroxide
GO_0035696Biological processmonocyte extravasation
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0009986Cellular componentcell surface
GO_0070821Cellular componenttertiary granule membrane
GO_0101003Cellular componentficolin-1-rich granule membrane
GO_0086080Molecular functionprotein binding involved in heterotypic cell-cell adhesion
GO_0019903Molecular functionprotein phosphatase binding
GO_0098632Molecular functioncell-cell adhesion mediator activity
GO_1990782Molecular functionprotein tyrosine kinase binding
GO_0030695Molecular functionGTPase regulator activity
GO_1990405Molecular functionprotein antigen binding
GO_0017124Molecular functionSH3 domain binding

IV. Literature review

[source]
Gene nameSIRPA
Protein nameTyrosine-protein phosphatase non-receptor type substrate 1 (SHP substrate 1) (SHPS-1) (Brain Ig-like molecule with tyrosine-based activation motifs) (Bit) (CD172 antigen-like family member A) (Inhibitory receptor SHPS-1) (Macrophage fusion receptor) (MyD-1 antigen) (Signal-regulatory protein alpha-1) (Sirp-alpha-1) (Signal-regulatory protein alpha-2) (Sirp-alpha-2) (Signal-regulatory protein alpha-3) (Sirp-alpha-3) (p84) (CD antigen CD172a)
SynonymsSHPS1
MFR
BIT
PTPNS1
MYD1
SIRP
DescriptionFUNCTION: Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Plays a role in antiviral immunity and limits new world arenavirus infection by decreasing virus internalization (By similarity). Receptor for THBS1 . Interaction with THBS1 stimulates phosphorylation of SIRPA (By similarity). In response to THBS1, involved in ROS signaling in non-phagocytic cells, stimulating NADPH oxidase-derived ROS production . .

AccessionsENST00000400068.7 [P78324-1]
ENST00000356025.7 [P78324-1]
P78324
ENST00000358771.5 [P78324-1]
ENST00000622179.4 [P78324-2]