SIMC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0030017Cellular componentsarcomere
GO_0016605Cellular componentPML body
GO_0005737Cellular componentcytoplasm
GO_0030414Molecular functionpeptidase inhibitor activity
GO_0005515Molecular functionprotein binding
GO_0032184Molecular functionSUMO polymer binding

IV. Literature review

[source]
Gene nameSIMC1
Protein nameSUMO-interacting motif-containing protein 1 (Platform element for inhibition of autolytic degradation)
SynonymsPLEIAD
C5orf25
DescriptionFUNCTION: Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication. .; FUNCTION: [Isoform 1]: Inhibits the protease activity of CAPN3. .; FUNCTION: [Isoform 5]: Inhibits the protease activity of CAPN3. .

AccessionsENST00000429602.7 [Q8NDZ2-5]
ENST00000332772.4 [Q8NDZ2-4]
ENST00000430704.6 [Q8NDZ2-3]
ENST00000443967.5 [Q8NDZ2-1]
ENST00000341199.10 [Q8NDZ2-3]
Q8NDZ2