SIGMAR1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070207Biological processprotein homotrimerization
GO_0043523Biological processregulation of neuron apoptotic process
GO_0038003Biological processG protein-coupled opioid receptor signaling pathway
GO_0007399Biological processnervous system development
GO_0006869Biological processlipid transport
GO_0098839Cellular componentpostsynaptic density membrane
GO_0005811Cellular componentlipid droplet
GO_0031410Cellular componentcytoplasmic vesicle
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0005637Cellular componentnuclear inner membrane
GO_0005640Cellular componentnuclear outer membrane
GO_0005635Cellular componentnuclear envelope
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0070161Cellular componentanchoring junction
GO_0014069Cellular componentpostsynaptic density
GO_0030426Cellular componentgrowth cone
GO_0004985Molecular functionG protein-coupled opioid receptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSIGMAR1
Protein nameSigma non-opioid intracellular receptor 1 (Sigma 1-type opioid receptor)
Sigma non-opioid intracellular receptor 1 (Aging-associated gene 8 protein) (SR31747-binding protein) (SR-BP) (Sigma 1-type opioid receptor) (SIG-1R) (Sigma1-receptor) (Sigma1R) (hSigmaR1)
SynonymsOPRS1
hCG_20471
AAG8
SRBP
DescriptionFUNCTION: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Involved in the regulation of different receptors it plays a role in BDNF signaling and EGF signaling. Also regulates ion channels like the potassium channel and could modulate neurotransmitter release. Plays a role in calcium signaling through modulation together with ANK2 of the ITP3R-dependent calcium efflux at the endoplasmic reticulum. Plays a role in several other cell functions including proliferation, survival and death. Originally identified for its ability to bind various psychoactive drugs it is involved in learning processes, memory and mood alteration . Necessary for proper mitochondrial axonal transport in motor neurons, in particular the retrograde movement of mitochondria. Plays a role in protecting cells against oxidative stress-induced cell death via its interaction with RNF112 (By similarity). .

FUNCTION: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum. .

FUNCTION: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum. .

FUNCTION: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum. .

FUNCTION: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum. .

FUNCTION: Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum. .

AccessionsB4DR71
ENST00000680730.1
ENST00000353468.4 [Q99720-4]
A0A7P0T9D5
ENST00000680244.1
ENST00000277010.9 [Q99720-1]
Q5T1J1
A0A7P0TA12
A0A7P0Z4C2
ENST00000680277.1
ENST00000679597.1 [Q99720-2]
ENST00000680104.1
Q99720
ENST00000378892.5
ENST00000477726.1 [Q99720-3]