SIGLEC7 | OmnibusX

Name	Number of supported studies	Average coverage
classical monocyte	3 studies	20% ± 3%	Explore
CD16-negative, CD56-bright natural killer cell, human	3 studies	17% ± 1%	Explore
CD16-positive, CD56-dim natural killer cell, human	3 studies	20% ± 4%	Explore
macrophage	3 studies	23% ± 6%	Explore

sc-RNAseq data

Insufficient scRNA-seq data for expression of SIGLEC7 at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
lung	99%	194.92	575 / 578	81%	3.36	940 / 1155
breast	81%	50.79	373 / 459	81%	2.32	902 / 1118
liver	99%	120.30	224 / 226	42%	1.04	170 / 406
intestine	80%	54.30	771 / 966	54%	1.65	287 / 527
bladder	81%	57.00	17 / 21	51%	1.55	258 / 504
kidney	52%	39.17	46 / 89	77%	3.68	695 / 901
adrenal gland	95%	127.52	245 / 258	25%	0.62	58 / 230
stomach	51%	24.46	183 / 359	67%	2.28	191 / 286
ovary	38%	17.36	68 / 180	75%	2.59	324 / 430
thymus	50%	19.77	325 / 653	56%	1.39	341 / 605
pancreas	28%	11.61	92 / 328	75%	2.56	133 / 178
lymph node	0%	0	0 / 0	100%	11.55	29 / 29
spleen	100%	820.49	241 / 241	0%	0	0 / 0
uterus	46%	18.68	79 / 170	51%	1.21	234 / 459
prostate	65%	31.02	160 / 245	32%	0.55	159 / 502
esophagus	47%	21.91	683 / 1445	49%	1.06	90 / 183
adipose	93%	97.80	1115 / 1204	0%	0	0 / 0
brain	22%	13.09	581 / 2642	68%	3.08	478 / 705
peripheral blood	83%	763.73	773 / 929	0%	0	0 / 0
skin	9%	2.61	155 / 1809	72%	3.22	339 / 472
blood vessel	65%	53.67	868 / 1335	0%	0	0 / 0
tonsil	0%	0	0 / 0	64%	1.92	29 / 45
heart	63%	33.69	545 / 861	0%	0	0 / 0
eye	0%	0	0 / 0	25%	0.53	20 / 80
muscle	4%	1.38	35 / 803	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

Gene name	SIGLEC7
Protein name	Sialic acid binding Ig like lectin 7 Sialic acid-binding Ig-like lectin 7 (Siglec-7) (Adhesion inhibitory receptor molecule 1) (AIRM-1) (CDw328) (D-siglec) (QA79 membrane protein) (p75) (CD antigen CD328)
Synonyms	AIRM1
Description	FUNCTION: Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- and alpha-2,6-linked sialic acid. Also binds disialogangliosides (disialogalactosyl globoside, disialyl lactotetraosylceramide and disialyl GalNAc lactotetraoslylceramide). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Mediates inhibition of natural killer cells cytotoxicity. May play a role in hemopoiesis. Inhibits differentiation of CD34+ cell precursors towards myelomonocytic cell lineage and proliferation of leukemic myeloid cells (in vitro). .
Accessions	ENST00000601682.1 ENST00000600577.1 [Q9Y286-4] ENST00000305628.7 [Q9Y286-2] ENST00000536156.5 [Q9Y286-3] Q9Y286 ENST00000317643.10 [Q9Y286-1] M0QY65

GO_0007155	Biological process	cell adhesion
GO_0005886	Cellular component	plasma membrane
GO_0038023	Molecular function	signaling receptor activity
GO_0030246	Molecular function	carbohydrate binding
GO_0005515	Molecular function	protein binding
GO_0033691	Molecular function	sialic acid binding

SIGLEC7 report