Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| macrophage | 8 studies | 23% ± 9% | |
| epithelial cell of proximal tubule | 7 studies | 37% ± 10% | |
| adipocyte | 6 studies | 20% ± 4% | |
| epithelial cell | 5 studies | 31% ± 7% | |
| hepatocyte | 4 studies | 56% ± 17% | |
| intestinal crypt stem cell | 3 studies | 15% ± 0% | |
| basal cell | 3 studies | 26% ± 1% | |
| transit amplifying cell | 3 studies | 32% ± 7% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 5 studies | 26% ± 7% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 2802.17 | 653 / 653 | 99% | 31.67 | 599 / 605 |
| liver | 100% | 20793.79 | 226 / 226 | 97% | 73.66 | 393 / 406 |
| skin | 98% | 1941.06 | 1776 / 1809 | 96% | 20.79 | 452 / 472 |
| ovary | 99% | 1193.72 | 178 / 180 | 94% | 16.13 | 403 / 430 |
| esophagus | 99% | 2733.02 | 1437 / 1445 | 93% | 16.01 | 170 / 183 |
| intestine | 99% | 1707.88 | 958 / 966 | 93% | 15.34 | 490 / 527 |
| kidney | 100% | 9838.22 | 89 / 89 | 92% | 73.66 | 829 / 901 |
| breast | 100% | 3758.34 | 459 / 459 | 92% | 13.93 | 1026 / 1118 |
| uterus | 94% | 992.04 | 160 / 170 | 95% | 22.35 | 438 / 459 |
| stomach | 97% | 1146.01 | 349 / 359 | 91% | 14.46 | 261 / 286 |
| bladder | 100% | 1168.76 | 21 / 21 | 86% | 14.62 | 434 / 504 |
| prostate | 99% | 1173.23 | 242 / 245 | 86% | 9.22 | 434 / 502 |
| lung | 83% | 1153.19 | 481 / 578 | 90% | 14.60 | 1041 / 1155 |
| pancreas | 78% | 516.60 | 256 / 328 | 69% | 7.39 | 122 / 178 |
| brain | 71% | 629.14 | 1864 / 2642 | 70% | 8.04 | 494 / 705 |
| eye | 0% | 0 | 0 / 0 | 100% | 50.43 | 80 / 80 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 23.84 | 45 / 45 |
| adipose | 100% | 3733.99 | 1203 / 1204 | 0% | 0 | 0 / 0 |
| adrenal gland | 87% | 923.56 | 224 / 258 | 13% | 1.25 | 30 / 230 |
| spleen | 99% | 2284.56 | 239 / 241 | 0% | 0 | 0 / 0 |
| muscle | 98% | 994.37 | 786 / 803 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 11.69 | 27 / 29 |
| blood vessel | 78% | 674.92 | 1043 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 49% | 592.91 | 453 / 929 | 0% | 0 | 0 / 0 |
| heart | 42% | 247.03 | 363 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0006544 | Biological process | glycine metabolic process |
| GO_1990830 | Biological process | cellular response to leukemia inhibitory factor |
| GO_0051289 | Biological process | protein homotetramerization |
| GO_0035999 | Biological process | tetrahydrofolate interconversion |
| GO_1904482 | Biological process | cellular response to tetrahydrofolate |
| GO_0019264 | Biological process | glycine biosynthetic process from serine |
| GO_0046655 | Biological process | folic acid metabolic process |
| GO_0046653 | Biological process | tetrahydrofolate metabolic process |
| GO_0006565 | Biological process | L-serine catabolic process |
| GO_0006231 | Biological process | dTMP biosynthetic process |
| GO_0009113 | Biological process | purine nucleobase biosynthetic process |
| GO_0017148 | Biological process | negative regulation of translation |
| GO_0006563 | Biological process | L-serine metabolic process |
| GO_0005739 | Cellular component | mitochondrion |
| GO_0070062 | Cellular component | extracellular exosome |
| GO_0005634 | Cellular component | nucleus |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0004372 | Molecular function | glycine hydroxymethyltransferase activity |
| GO_0048027 | Molecular function | mRNA 5'-UTR binding |
| GO_0030170 | Molecular function | pyridoxal phosphate binding |
| GO_0070905 | Molecular function | serine binding |
| GO_0000900 | Molecular function | mRNA regulatory element binding translation repressor activity |
| GO_0042802 | Molecular function | identical protein binding |
| GO_0036094 | Molecular function | small molecule binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SHMT1 |
| Protein name | Serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) (EC 3.4.19.12) (Glycine hydroxymethyltransferase) (Serine methylase) Serine hydroxymethyltransferase, cytosolic (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase) |
| Synonyms | |
| Description | FUNCTION: Interconversion of serine and glycine . . |
| Accessions | P34896 ENST00000582653.1 J3KRZ5 ENST00000352886.10 [P34896-4] ENST00000580002.5 ENST00000354098.7 [P34896-2] ENST00000316694.8 [P34896-1] ENST00000640392.2 [P34896-1] J3KRK5 ENST00000644141.2 [P34896-1] |
