SH2B1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048870Biological processcell motility
GO_0035556Biological processintracellular signal transduction
GO_0060391Biological processpositive regulation of SMAD protein signal transduction
GO_0007169Biological processcell surface receptor protein tyrosine kinase signaling pathway
GO_0045840Biological processpositive regulation of mitotic nuclear division
GO_2000278Biological processregulation of DNA biosynthetic process
GO_0030032Biological processlamellipodium assembly
GO_0005829Cellular componentcytosol
GO_0005886Cellular componentplasma membrane
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0005068Molecular functiontransmembrane receptor protein tyrosine kinase adaptor activity

IV. Literature review

[source]
Gene nameSH2B1
Protein nameSH2B adapter protein 1 (Pro-rich, PH and SH2 domain-containing signaling mediator) (PSM) (SH2 domain-containing protein 1B)
SH2B adaptor protein 1
SH2B adaptor protein 1 (cDNA FLJ59336, highly similar to Homo sapiens SH2-B homolog (SH2B), mRNA)
SynonymsKIAA1299
SH2B
DescriptionFUNCTION: Adapter protein for several members of the tyrosine kinase receptor family. Involved in multiple signaling pathways mediated by Janus kinase (JAK) and receptor tyrosine kinases, including the receptors of insulin (INS), insulin-like growth factor I (IGF1), nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), glial cell line-derived neurotrophic factor (GDNF), platelet-derived growth factor (PDGF) and fibroblast growth factors (FGFs). In growth hormone (GH) signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1, which in turn is phosphorylated by JAK2 on tyrosine residues. These phosphotyrosines form potential binding sites for other signaling proteins. GH also promotes serine/threonine phosphorylation of SH2B1 and these phosphorylated residues may serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes, such as RAC1. In leptin (LEP) signaling, binds to and potentiates the activation of JAK2 by globally enhancing downstream pathways. In response to leptin, binds simultaneously to both, JAK2 and IRS1 or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2, resulting in activation of the PI 3-kinase pathway. Acts as a positive regulator of NGF-mediated activation of the Akt/Forkhead pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473' and AKT1 enzymatic activity. Enhances the kinase activity of the cytokine receptor-associated tyrosine kinase JAK2 and of other receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the mechanism seems to involve dimerization of both, SH2B1 and JAK2. Enhances RET phosphorylation and kinase activity. Isoforms seem to be differentially involved in IGF-I and PDGF-induced mitogenesis (By similarity). .

AccessionsH3BMY3
ENST00000322610.12 [Q9NRF2-1]
H3BVF6
B4DLN5
ENST00000563591.5
ENST00000567536.5
ENST00000395532.8 [Q9NRF2-2]
ENST00000569651.1
H3BPB4
ENST00000684370.1 [Q9NRF2-1]
ENST00000566209.1
ENST00000707128.1 [Q9NRF2-2]
ENST00000359285.10 [Q9NRF2-3]
ENST00000337120.9 [Q9NRF2-2]
Q9NRF2
ENST00000561629.1
H3BUN7
H3BPZ4
ENST00000538342.5
ENST00000566176.5
ENST00000545570.5
H3BTK4
ENST00000618521.4 [Q9NRF2-1]
F5GXU7