I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 10 studies | 27% ± 11% | |
| pericyte | 8 studies | 19% ± 4% | |
| myofibroblast cell | 4 studies | 25% ± 8% | |
| muscle cell | 3 studies | 28% ± 15% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| smooth muscle cell | 10 studies | 27% ± 11% | |
| pericyte | 8 studies | 19% ± 4% | |
| myofibroblast cell | 4 studies | 25% ± 8% | |
| muscle cell | 3 studies | 28% ± 15% |
Insufficient scRNA-seq data for expression of SGCA at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 94% | 1912.59 | 541 / 578 | 76% | 4.68 | 875 / 1155 |
| prostate | 70% | 1688.20 | 171 / 245 | 99% | 14.95 | 496 / 502 |
| bladder | 86% | 3138.10 | 18 / 21 | 51% | 3.55 | 257 / 504 |
| intestine | 69% | 2118.51 | 662 / 966 | 52% | 2.64 | 272 / 527 |
| esophagus | 65% | 3063.74 | 939 / 1445 | 52% | 2.90 | 95 / 183 |
| uterus | 76% | 1754.15 | 130 / 170 | 31% | 9.54 | 141 / 459 |
| skin | 19% | 241.77 | 339 / 1809 | 82% | 4.24 | 386 / 472 |
| muscle | 100% | 17441.13 | 803 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 8611.49 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| stomach | 40% | 1212.45 | 142 / 359 | 58% | 3.87 | 167 / 286 |
| heart | 97% | 5646.42 | 836 / 861 | 0% | 0 | 0 / 0 |
| pancreas | 0% | 0 | 0 / 328 | 83% | 4.53 | 148 / 178 |
| eye | 0% | 0 | 0 / 0 | 74% | 2.49 | 59 / 80 |
| kidney | 2% | 31.51 | 2 / 89 | 60% | 2.48 | 537 / 901 |
| thymus | 4% | 53.02 | 24 / 653 | 50% | 4.55 | 304 / 605 |
| brain | 5% | 50.41 | 126 / 2642 | 48% | 1.21 | 337 / 705 |
| adrenal gland | 0% | 0 | 0 / 258 | 52% | 2.48 | 120 / 230 |
| liver | 1% | 14.50 | 3 / 226 | 46% | 1.83 | 185 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 41% | 1.61 | 12 / 29 |
| breast | 7% | 93.82 | 34 / 459 | 23% | 0.66 | 261 / 1118 |
| adipose | 24% | 406.57 | 290 / 1204 | 0% | 0 | 0 / 0 |
| ovary | 9% | 191.12 | 16 / 180 | 8% | 0.36 | 35 / 430 |
| tonsil | 0% | 0 | 0 / 0 | 13% | 1.10 | 6 / 45 |
| spleen | 4% | 39.57 | 9 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 1% | 13.78 | 8 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0014894 | Biological process | response to denervation involved in regulation of muscle adaptation |
| GO_0043403 | Biological process | skeletal muscle tissue regeneration |
| GO_0006936 | Biological process | muscle contraction |
| GO_0007517 | Biological process | muscle organ development |
| GO_0016012 | Cellular component | sarcoglycan complex |
| GO_0005911 | Cellular component | cell-cell junction |
| GO_0042383 | Cellular component | sarcolemma |
| GO_0005856 | Cellular component | cytoskeleton |
| GO_0016010 | Cellular component | dystrophin-associated glycoprotein complex |
| GO_0045121 | Cellular component | membrane raft |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005509 | Molecular function | calcium ion binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | SGCA |
| Protein name | Sarcoglycan alpha isoform 2 (Sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein), isoform CRA_a) Sarcoglycan alpha Alpha-sarcoglycan (Alpha-SG) (50 kDa dystrophin-associated glycoprotein) (50DAG) (Adhalin) (Dystroglycan-2) Sarcoglycan alpha isoform 1 Alternative protein SGCA |
| Synonyms | hCG_29610 ADL DAG2 |
| Description | FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. . FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. . FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. . FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. . FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. . FUNCTION: Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. . |
| Accessions | ENST00000504073.2 H0YAB9 A0A804HKZ6 A0A804HKR7 D6R9S3 A0A0S2Z4P8 ENST00000513821.5 ENST00000512526.2 ENST00000514934.1 L8EC52 ENST00000262018.8 [Q16586-1] E9PCT8 Q16586 ENST00000344627.10 [Q16586-2] A0A0S2Z4Q1 ENST00000683294.1 ENST00000502555.5 H0Y8T1 D6RAA4 ENST00000682109.1 |
