SENP2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0016925Biological processprotein sumoylation
GO_0051028Biological processmRNA transport
GO_0031648Biological processprotein destabilization
GO_0016926Biological processprotein desumoylation
GO_0006508Biological processproteolysis
GO_0015031Biological processprotein transport
GO_0031398Biological processpositive regulation of protein ubiquitination
GO_0016055Biological processWnt signaling pathway
GO_0030111Biological processregulation of Wnt signaling pathway
GO_0045444Biological processfat cell differentiation
GO_0031397Biological processnegative regulation of protein ubiquitination
GO_0005643Cellular componentnuclear pore
GO_0005634Cellular componentnucleus
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0016605Cellular componentPML body
GO_0031965Cellular componentnuclear membrane
GO_0016929Molecular functiondeSUMOylase activity
GO_0070139Molecular functionSUMO-specific endopeptidase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSENP2
Protein nameSUMO specific peptidase 2
Sentrin-specific protease 2 (EC 3.4.22.-) (Axam2) (SMT3-specific isopeptidase 2) (Smt3ip2) (Sentrin/SUMO-specific protease SENP2)
SynonymsKIAA1331
DescriptionFUNCTION: Protease that catalyzes two essential functions in the SUMO pathway . The first is the hydrolysis of an alpha-linked peptide bond at the C-terminal end of the small ubiquitin-like modifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to the mature form of the proteins . The second is the deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving an epsilon-linked peptide bond between the C-terminal glycine of the mature SUMO and the lysine epsilon-amino group of the target protein . May down-regulate CTNNB1 levels and thereby modulate the Wnt pathway (By similarity). Deconjugates SUMO2 from MTA1 . Plays a dynamic role in adipogenesis by desumoylating and promoting the stabilization of CEBPB . Acts as a regulator of the cGAS-STING pathway by catalyzing desumoylation of CGAS and STING1 during the late phase of viral infection (By similarity). .

AccessionsF8WCX8
F8WED6
ENST00000296257.10 [Q9HC62-1]
F8WET6
ENST00000430355.5
ENST00000453532.5
Q9HC62
F8WED7
C9IYB7
ENST00000444509.1
ENST00000413407.5
H7C1A0
ENST00000439684.5
ENST00000458551.1