SELENON report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SELENON at tissue level.

III. Associated gene sets

GO_0048741Biological processskeletal muscle fiber development
GO_0055074Biological processcalcium ion homeostasis
GO_0034599Biological processcellular response to oxidative stress
GO_0007005Biological processmitochondrion organization
GO_1902884Biological processpositive regulation of response to oxidative stress
GO_0014858Biological processpositive regulation of skeletal muscle cell proliferation
GO_0014816Biological processskeletal muscle satellite cell differentiation
GO_0014873Biological processresponse to muscle activity involved in regulation of muscle adaptation
GO_0033555Biological processmulticellular organismal response to stress
GO_0060314Biological processregulation of ryanodine-sensitive calcium-release channel activity
GO_0003016Biological processrespiratory system process
GO_0014834Biological processskeletal muscle satellite cell maintenance involved in skeletal muscle regeneration
GO_0048286Biological processlung alveolus development
GO_0071313Biological processcellular response to caffeine
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016491Molecular functionoxidoreductase activity
GO_0005509Molecular functioncalcium ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameSELENON
Protein nameSelenoprotein N
Selenoprotein N (SelN)
SynonymsSELN
SEPN1
DescriptionFUNCTION: [Isoform 2]: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity . Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation . .; FUNCTION: Essential for muscle regeneration and satellite cell maintenance in skeletal muscle . .

AccessionsH9KV50
ENST00000494537.2
ENST00000361547.7 [Q9NZV5-1]
ENST00000354177.9
ENST00000374315.1 [Q9NZV5-2]
Q9NZV5
A0A804HLD6