SEC24A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0050714Biological processpositive regulation of protein secretion
GO_0006886Biological processintracellular protein transport
GO_0006888Biological processendoplasmic reticulum to Golgi vesicle-mediated transport
GO_0032374Biological processregulation of cholesterol transport
GO_0042632Biological processcholesterol homeostasis
GO_0090110Biological processCOPII-coated vesicle cargo loading
GO_0012507Cellular componentER to Golgi transport vesicle membrane
GO_0005829Cellular componentcytosol
GO_0030127Cellular componentCOPII vesicle coat
GO_0070971Cellular componentendoplasmic reticulum exit site
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0000149Molecular functionSNARE binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameSEC24A
Protein nameSEC24 homolog A, COPII coat complex component
Protein transport protein Sec24A (SEC24-related protein A)
Synonyms
DescriptionFUNCTION: Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules for their transport to the Golgi complex . Plays a central role in cargo selection within the COPII complex and together with SEC24B may have a different specificity compared to SEC24C and SEC24D. May package preferentially cargos with cytoplasmic DxE or LxxLE motifs and may also recognize conformational epitopes . .

AccessionsENST00000322887.8 [O95486-2]
ENST00000513123.1
ENST00000398844.7 [O95486-1]
H0Y9J6
O95486