SDHAF4 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of SDHAF4 at tissue level.

III. Associated gene sets

GO_0034553Biological processmitochondrial respiratory chain complex II assembly
GO_0045333Biological processcellular respiration
GO_0045087Biological processinnate immune response
GO_0005575Cellular componentcellular_component
GO_0005759Cellular componentmitochondrial matrix
GO_0005739Cellular componentmitochondrion
GO_0008047Molecular functionenzyme activator activity
GO_0005515Molecular functionprotein binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameSDHAF4
Protein nameSuccinate dehydrogenase assembly factor 4, mitochondrial
Succinate dehydrogenase assembly factor 4, mitochondrial (SDH assembly factor 4) (SDHAF4)
SynonymsC6orf57
DescriptionFUNCTION: Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol . Binds to the flavoprotein subunit SDHA in its FAD-bound form, blocking the generation of excess reactive oxygen species (ROS) and facilitating its assembly with the iron-sulfur protein subunit SDHB into the SDH catalytic dimer (By similarity). .

AccessionsI6L976
ENST00000370474.4
Q5VUM1