SCN8A | OmnibusX

I. Expression across cell types

Name	Number of supported studies	Average coverage
glutamatergic neuron	12 studies	64% ± 25%	Explore
GABAergic neuron	11 studies	52% ± 26%	Explore
oligodendrocyte precursor cell	10 studies	31% ± 10%	Explore
neuron	6 studies	43% ± 11%	Explore
astrocyte	6 studies	29% ± 16%	Explore
interneuron	6 studies	59% ± 21%	Explore
retinal ganglion cell	6 studies	45% ± 14%	Explore
granule cell	4 studies	53% ± 11%	Explore
amacrine cell	4 studies	29% ± 6%	Explore
GABAergic interneuron	3 studies	57% ± 3%	Explore
OFF-bipolar cell	3 studies	26% ± 6%	Explore
ON-bipolar cell	3 studies	24% ± 6%	Explore
glycinergic amacrine cell	3 studies	21% ± 7%	Explore

II. Expression across tissues

Name	Number of supported studies	Average coverage
brain	15 studies	40% ± 24%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
brain	95%	4449.89	2519 / 2642	96%	6.56	676 / 705
liver	90%	662.63	204 / 226	50%	1.07	205 / 406
pancreas	70%	380.48	229 / 328	40%	0.71	71 / 178
adrenal gland	29%	163.09	74 / 258	77%	4.78	176 / 230
prostate	52%	275.68	127 / 245	32%	0.55	161 / 502
kidney	48%	316.70	43 / 89	28%	0.59	256 / 901
ovary	11%	37.51	19 / 180	55%	1.25	237 / 430
skin	29%	868.29	517 / 1809	29%	0.72	139 / 472
intestine	21%	114.41	207 / 966	35%	0.74	185 / 527
esophagus	0%	1.68	7 / 1445	53%	1.55	97 / 183
breast	18%	87.23	81 / 459	35%	0.91	392 / 1118
stomach	8%	36.79	29 / 359	36%	0.78	104 / 286
uterus	9%	43.62	16 / 170	32%	0.76	147 / 459
lung	1%	5.20	8 / 578	38%	0.90	444 / 1155
spleen	39%	164.81	93 / 241	0%	0	0 / 0
thymus	14%	77.63	94 / 653	17%	0.31	105 / 605
bladder	5%	15.81	1 / 21	25%	0.58	126 / 504
tonsil	0%	0	0 / 0	27%	0.47	12 / 45
eye	0%	0	0 / 0	13%	0.22	10 / 80
lymph node	0%	0	0 / 0	7%	0.17	2 / 29
adipose	3%	12.22	34 / 1204	0%	0	0 / 0
peripheral blood	1%	5.49	9 / 929	0%	0	0 / 0
blood vessel	0%	0.73	2 / 1335	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
heart	0%	0	0 / 861	0%	0	0 / 0
muscle	0%	0	0 / 803	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

III. Associated gene sets

GO_0086002	Biological process	cardiac muscle cell action potential involved in contraction
GO_0042552	Biological process	myelination
GO_0021554	Biological process	optic nerve development
GO_0006814	Biological process	sodium ion transport
GO_0019228	Biological process	neuronal action potential
GO_0007422	Biological process	peripheral nervous system development
GO_0007399	Biological process	nervous system development
GO_0035725	Biological process	sodium ion transmembrane transport
GO_0098978	Cellular component	glutamatergic synapse
GO_0098839	Cellular component	postsynaptic density membrane
GO_0005886	Cellular component	plasma membrane
GO_0031410	Cellular component	cytoplasmic vesicle
GO_0016020	Cellular component	membrane
GO_0030018	Cellular component	Z disc
GO_0048787	Cellular component	presynaptic active zone membrane
GO_0043194	Cellular component	axon initial segment
GO_0033268	Cellular component	node of Ranvier
GO_0001518	Cellular component	voltage-gated sodium channel complex
GO_0030054	Cellular component	cell junction
GO_0030424	Cellular component	axon
GO_0098688	Cellular component	parallel fiber to Purkinje cell synapse
GO_0005248	Molecular function	voltage-gated sodium channel activity
GO_0005524	Molecular function	ATP binding
GO_0005515	Molecular function	protein binding
GO_0031402	Molecular function	sodium ion binding

IV. Literature review

[source]

Gene name	SCN8A
Protein name	Sodium voltage-gated channel alpha subunit 8 Sodium channel protein Nav1.6 Voltage-gated sodium channel Nav1.6 Voltage-gated sodium channel (Nav1.6) Sodium channel protein type 8 subunit alpha (Sodium channel protein type VIII subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.6)
Synonyms	MED
Description	FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes . Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .; FUNCTION: [Isoform 5]: In macrophages and melanoma cells, may participate in the control of podosome and invadopodia formation. . FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. . FUNCTION: Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. .
Accessions	Q8WWN3 ENST00000627620.5 [Q9UQD0-2] A0A1B0GVD4 ENST00000636945.2 Q9P2Q6 Q9UQD0 Q6B4S3 ENST00000545061.5 [Q9UQD0-5] Q6B4S2 A0A1W2PQI5 A0A590UJP2 ENST00000599343.5 [Q9UQD0-3] ENST00000551216.2 Q6B4S4 ENST00000638820.1 A0A590UK43 ENST00000355133.7 [Q9UQD0-5] ENST00000548086.3 ENST00000637709.2 ENST00000667214.1 ENST00000662684.1 [Q9UQD0-2] A0A590UK68 ENST00000668547.1 A0A1B0GVM8 F8W0Q0 Q9GZR0 ENST00000354534.11 [Q9UQD0-1]

SCN8A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

IV. Literature review