Name | Number of supported studies | Average coverage | |
---|---|---|---|
microglial cell | 9 studies | 40% ± 14% | |
renal alpha-intercalated cell | 7 studies | 65% ± 9% | |
ciliated cell | 6 studies | 21% ± 5% | |
enterocyte | 6 studies | 25% ± 5% | |
goblet cell | 5 studies | 34% ± 31% | |
renal principal cell | 5 studies | 56% ± 10% | |
ionocyte | 3 studies | 38% ± 10% | |
kidney loop of Henle epithelial cell | 3 studies | 29% ± 11% | |
epithelial cell | 3 studies | 42% ± 6% | |
mast cell | 3 studies | 22% ± 7% | |
kidney distal convoluted tubule epithelial cell | 3 studies | 32% ± 8% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
kidney | 100% | 6528.36 | 89 / 89 | 81% | 38.23 | 733 / 901 |
prostate | 94% | 637.99 | 230 / 245 | 57% | 6.24 | 284 / 502 |
lung | 90% | 660.23 | 523 / 578 | 50% | 8.09 | 581 / 1155 |
brain | 59% | 569.50 | 1564 / 2642 | 68% | 10.37 | 479 / 705 |
bladder | 71% | 705.05 | 15 / 21 | 38% | 4.95 | 190 / 504 |
skin | 70% | 358.41 | 1261 / 1809 | 39% | 15.28 | 186 / 472 |
stomach | 75% | 831.77 | 270 / 359 | 34% | 2.46 | 96 / 286 |
intestine | 61% | 2046.25 | 586 / 966 | 47% | 3.88 | 246 / 527 |
esophagus | 61% | 1218.90 | 876 / 1445 | 40% | 3.38 | 74 / 183 |
ureter | 0% | 0 | 0 / 0 | 100% | 7.97 | 1 / 1 |
pancreas | 21% | 50.63 | 69 / 328 | 65% | 7.08 | 115 / 178 |
breast | 44% | 146.67 | 203 / 459 | 28% | 4.77 | 312 / 1118 |
adipose | 67% | 390.68 | 805 / 1204 | 0% | 0 | 0 / 0 |
thymus | 56% | 175.07 | 365 / 653 | 9% | 1.00 | 56 / 605 |
uterus | 35% | 128.54 | 59 / 170 | 30% | 2.69 | 138 / 459 |
tonsil | 0% | 0 | 0 / 0 | 36% | 3.43 | 16 / 45 |
blood vessel | 32% | 118.42 | 427 / 1335 | 0% | 0 | 0 / 0 |
adrenal gland | 23% | 55.20 | 59 / 258 | 5% | 0.43 | 11 / 230 |
ovary | 23% | 51.74 | 42 / 180 | 3% | 0.49 | 15 / 430 |
eye | 0% | 0 | 0 / 0 | 25% | 13.07 | 20 / 80 |
peripheral blood | 10% | 48.75 | 92 / 929 | 0% | 0 | 0 / 0 |
muscle | 3% | 7.27 | 26 / 803 | 0% | 0 | 0 / 0 |
heart | 3% | 7.53 | 24 / 861 | 0% | 0 | 0 / 0 |
liver | 0% | 0 | 0 / 226 | 2% | 0.14 | 8 / 406 |
spleen | 1% | 1.50 | 2 / 241 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0008285 | Biological process | negative regulation of cell population proliferation |
GO_0045654 | Biological process | positive regulation of megakaryocyte differentiation |
GO_0051016 | Biological process | barbed-end actin filament capping |
GO_0017156 | Biological process | calcium-ion regulated exocytosis |
GO_0030031 | Biological process | cell projection assembly |
GO_0051693 | Biological process | actin filament capping |
GO_0045010 | Biological process | actin nucleation |
GO_0008154 | Biological process | actin polymerization or depolymerization |
GO_0042989 | Biological process | sequestering of actin monomers |
GO_0051014 | Biological process | actin filament severing |
GO_0051127 | Biological process | positive regulation of actin nucleation |
GO_0007417 | Biological process | central nervous system development |
GO_0051047 | Biological process | positive regulation of secretion |
GO_0032330 | Biological process | regulation of chondrocyte differentiation |
GO_0043065 | Biological process | positive regulation of apoptotic process |
GO_0005903 | Cellular component | brush border |
GO_0002102 | Cellular component | podosome |
GO_0070062 | Cellular component | extracellular exosome |
GO_0015629 | Cellular component | actin cytoskeleton |
GO_0005938 | Cellular component | cell cortex |
GO_0070161 | Cellular component | anchoring junction |
GO_0005737 | Cellular component | cytoplasm |
GO_0042995 | Cellular component | cell projection |
GO_0005546 | Molecular function | phosphatidylinositol-4,5-bisphosphate binding |
GO_0051015 | Molecular function | actin filament binding |
GO_0001786 | Molecular function | phosphatidylserine binding |
GO_0005545 | Molecular function | 1-phosphatidylinositol binding |
GO_0005509 | Molecular function | calcium ion binding |
GO_0003779 | Molecular function | actin binding |
Gene name | SCIN |
Protein name | Scinderin (Adseverin) |
Synonyms | KIAA1905 |
Description | FUNCTION: Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane . Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles . Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways . . |
Accessions | E5RHX6 E5RHN8 ENST00000297029.10 [Q9Y6U3-1] F8WBX5 C9JGB6 ENST00000518849.1 ENST00000523729.5 Q75MG0 Q9Y6U3 ENST00000341757.9 [Q9Y6U3-2] ENST00000436854.1 ENST00000417018.1 ENST00000519209.5 [Q9Y6U3-3] |