SCIN report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0008285Biological processnegative regulation of cell population proliferation
GO_0045654Biological processpositive regulation of megakaryocyte differentiation
GO_0051016Biological processbarbed-end actin filament capping
GO_0017156Biological processcalcium-ion regulated exocytosis
GO_0030031Biological processcell projection assembly
GO_0051693Biological processactin filament capping
GO_0045010Biological processactin nucleation
GO_0008154Biological processactin polymerization or depolymerization
GO_0042989Biological processsequestering of actin monomers
GO_0051014Biological processactin filament severing
GO_0051127Biological processpositive regulation of actin nucleation
GO_0007417Biological processcentral nervous system development
GO_0051047Biological processpositive regulation of secretion
GO_0032330Biological processregulation of chondrocyte differentiation
GO_0043065Biological processpositive regulation of apoptotic process
GO_0005903Cellular componentbrush border
GO_0002102Cellular componentpodosome
GO_0070062Cellular componentextracellular exosome
GO_0015629Cellular componentactin cytoskeleton
GO_0005938Cellular componentcell cortex
GO_0070161Cellular componentanchoring junction
GO_0005737Cellular componentcytoplasm
GO_0042995Cellular componentcell projection
GO_0005546Molecular functionphosphatidylinositol-4,5-bisphosphate binding
GO_0051015Molecular functionactin filament binding
GO_0001786Molecular functionphosphatidylserine binding
GO_0005545Molecular function1-phosphatidylinositol binding
GO_0005509Molecular functioncalcium ion binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameSCIN
Protein nameScinderin (Adseverin)
SynonymsKIAA1905
DescriptionFUNCTION: Ca(2+)-dependent actin filament-severing protein that has a regulatory function in exocytosis by affecting the organization of the microfilament network underneath the plasma membrane . Severing activity is inhibited by phosphatidylinositol 4,5-bis-phosphate (PIP2) (By similarity). In vitro, also has barbed end capping and nucleating activities in the presence of Ca(2+). Required for megakaryocyte differentiation, maturation, polyploidization and apoptosis with the release of platelet-like particles . Plays a role in osteoclastogenesis (OCG) and actin cytoskeletal organization in osteoclasts (By similarity). Regulates chondrocyte proliferation and differentiation (By similarity). Inhibits cell proliferation and tumorigenesis. Signaling is mediated by MAPK, p38 and JNK pathways . .

AccessionsE5RHX6
E5RHN8
ENST00000297029.10 [Q9Y6U3-1]
F8WBX5
C9JGB6
ENST00000518849.1
ENST00000523729.5
Q75MG0
Q9Y6U3
ENST00000341757.9 [Q9Y6U3-2]
ENST00000436854.1
ENST00000417018.1
ENST00000519209.5 [Q9Y6U3-3]