SBNO2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0071222Biological processcellular response to lipopolysaccharide
GO_0002281Biological processmacrophage activation involved in immune response
GO_0061430Biological processbone trabecula morphogenesis
GO_1990830Biological processcellular response to leukemia inhibitory factor
GO_0050727Biological processregulation of inflammatory response
GO_0071348Biological processcellular response to interleukin-11
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0030282Biological processbone mineralization
GO_0030316Biological processosteoclast differentiation
GO_0071354Biological processcellular response to interleukin-6
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0072675Biological processosteoclast fusion
GO_0005575Cellular componentcellular_component
GO_0005634Cellular componentnucleus
GO_0031490Molecular functionchromatin DNA binding
GO_0042393Molecular functionhistone binding

IV. Literature review

[source]
Gene nameSBNO2
Protein nameSBNO2 protein
Protein strawberry notch homolog 2
Strawberry notch homolog 2
SynonymsKIAA0963
DescriptionFUNCTION: Acts as a transcriptional coregulator, that can have both coactivator and corepressor functions. Inhibits the DCSTAMP-repressive activity of TAL1, hence enhancing the access of the transcription factor MITF to the DC-STAMP promoter in osteoclast. Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP-dependent pathway. May also be required in the regulation of osteoblast differentiation (By similarity). Involved in the transcriptional corepression of NF-kappaB in macrophages . Plays a role as a regulator in the pro-inflammatory cascade . .

AccessionsENST00000590998.5
ENST00000631778.1
K7ERL2
Q9Y2G9
ENST00000632777.1
ENST00000587655.2
ENST00000587024.5
ENST00000634172.1
K7ENA9
K7ES28
ENST00000590176.5
ENST00000622719.2 [Q9Y2G9-3]
ENST00000633604.1
ENST00000612198.3 [Q9Y2G9-1]
ENST00000438103.6 [Q9Y2G9-3]
ENST00000631948.1 [Q9Y2G9-1]
A0JNW0
ENST00000361757.8 [Q9Y2G9-1]