RUSC1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000209Biological processprotein polyubiquitination
GO_0014069Cellular componentpostsynaptic density
GO_0005829Cellular componentcytosol
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005794Cellular componentGolgi apparatus
GO_0005769Cellular componentearly endosome
GO_0031410Cellular componentcytoplasmic vesicle
GO_0005874Cellular componentmicrotubule
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0003779Molecular functionactin binding

IV. Literature review

[source]
Gene nameRUSC1
Protein nameRUN and SH3 domain containing 1
AP-4 complex accessory subunit RUSC1 (New molecule containing SH3 at the carboxy-terminus) (Nesca) (RUN and SH3 domain-containing protein 1)
SynonymsDKFZp761A1822
NESCA
hCG_2039583
DescriptionFUNCTION: Associates with the adapter-like complex 4 (AP-4) and may therefore play a role in vesicular trafficking of proteins at the trans-Golgi network . Signaling adapter which plays a role in neuronal differentiation . Involved in regulation of NGF-dependent neurite outgrowth . May play a role in neuronal vesicular trafficking, specifically involving pre-synaptic membrane proteins (By similarity). Seems to be involved in signaling pathways that are regulated by the prolonged activation of MAPK . Can regulate the polyubiquitination of IKBKG and thus may be involved in regulation of the NF-kappa-B pathway . .

AccessionsENST00000471876.5
ENST00000368352.10 [Q9BVN2-1]
A0A087WYU8
Q9BVN2
A0A087WX95
ENST00000479924.5
ENST00000292254.8 [Q9BVN2-2]
Q68CX2
ENST00000497930.6
A0A087WZ68
ENST00000490373.5
ENST00000368347.8 [Q9BVN2-3]
ENST00000696599.1
A0A087WYB2
A0A8Q3SIT1
A0A087WW20
A0A087WVK5
ENST00000485924.2
ENST00000489860.5
ENST00000468764.5
ENST00000368354.7 [Q9BVN2-4]
ENST00000368349.8 [Q9BVN2-2]